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Target
Serine/threonine-protein kinase Nek4
Ligand
BDBM50613380
Substrate
n/a
Meas. Tech.
ChEMBL_2292067
IC50
1000±n/a nM
Citation
 Wells, CI; Kapadia, NR; Couņago, RM; Drewry, DH In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases. Medchemcomm 9:44-66 (2018) [PubMed]
Target
Name:
Serine/threonine-protein kinase Nek4
Synonyms:
NEK kinase | NEK4 | NEK4_HUMAN | STK2
Type:
PROTEIN
Mol. Mass.:
94610.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774384
Residue:
841
Sequence:
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMNF
  
Inhibitor
Name:
BDBM50613380
Synonyms:
CHEMBL1988153
Type:
Small organic molecule
Emp. Form.:
C17H10F3N3O2S
Mol. Mass.:
377.34
SMILES:
Cc1nnc(o1)-c1cc2c(Oc3ccc(cc3)C(F)(F)F)cncc2s1
Structure:
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