Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 3
Ligand
BDBM50208135
Substrate
n/a
Meas. Tech.
ChEMBL_429282 (CHEMBL915841)
EC50
180±n/a nM
Citation
Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Gharbaoui, T; Boatman, PD; Sage, CR; Chen, R; Richman, JG; Connolly, DT; Semple, G Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem 50:1445-8 (2007) [PubMed] Article
More Info.:
Target
Name:
Hydroxycarboxylic acid receptor 3
Synonyms:
G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44498.06
Organism:
Homo sapiens (Human)
Description:
GPR109B 0 HUMAN::P49019
Residue:
387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
Inhibitor
Name:
BDBM50208135
Synonyms:
(+)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-dihydro-furan-2-carboxylic acid | (-)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-dihydro-furan-2-carboxylic acid | 5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-dihydro-furan-2-carboxylic acid | CHEMBL424938
Type:
Small organic molecule
Emp. Form.:
C11H10O4S
Mol. Mass.:
238.26
SMILES:
Cc1cc(cs1)C1(C)OC(=CC1=O)C(O)=O |c:10|