Reaction Details  Report a problem with these data
Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50265823
Substrate
n/a
Meas. Tech.
ChEMBL_544523 (CHEMBL1014287)
IC50
1200±n/a nM
Citation
 Wilk, W; Waldmann, H; Kaiser, M Gamma-pyrone natural products--a privileged compound class provided by nature. Bioorg Med Chem 17:2304-9 (2009) [PubMed]  Article
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50265823
Synonyms:
CHEMBL516634 | candelalide B
Type:
Small organic molecule
Emp. Form.:
C28H40O6
Mol. Mass.:
472.6136
SMILES:
COc1oc(C)c(C)c(=O)c1C[C@@H]1C(=C)CC[C@H]2[C@@]3(C)CC(=O)C(O[C@@H]3CC[C@]12C)C(C)(C)O |r|
Structure:
Search PDB for entries with ligand similarity: