Reaction Details  Report a problem with these data
Target
3-phosphoshikimate 1-carboxyvinyltransferase
Ligand
BDBM50281343
Substrate
n/a
Meas. Tech.
ChEMBL_65094 (CHEMBL670571)
Ki
1500±n/a nM
Citation
 Corey, SD; Pansegrau, PD; Walker, MC; Sikorski, JA EPSP synthase inhibitor deisgn III. Synthesis & evaluation of a new 5-oxamic acid analog of EPSP which incorporates a malonate ether as a 3-phosphate mimic Bioorg Med Chem Lett 3:2857-2862 (1993)    Article
Target
Name:
3-phosphoshikimate 1-carboxyvinyltransferase
Synonyms:
5-enolpyruvylshikimate-3-phosphate synthase | AROA_ECOLI | aroA
Type:
PROTEIN
Mol. Mass.:
46089.22
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_65087
Residue:
427
Sequence:
MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA
  
Inhibitor
Name:
BDBM50281343
Synonyms:
(3R,4S,5R)-5-Carboxymethoxy-4-hydroxy-3-phosphonooxy-cyclohex-1-enecarboxylic acid | CHEMBL318618
Type:
Small organic molecule
Emp. Form.:
C9H13O10P
Mol. Mass.:
312.1673
SMILES:
O[C@H]1[C@@H](CC(=C[C@H]1OP(O)(O)=O)C(O)=O)OCC(O)=O |c:4|
Structure:
Search PDB for entries with ligand similarity: