Reaction Details  Report a problem with these data
Target
Protein kinase C alpha type
Ligand
BDBM50281846
Substrate
n/a
Meas. Tech.
ChEBML_162570
Ki
200±n/a nM
Citation
 Lee, J; Lewin, NE; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 9.1 the effect of side-chain orientation on the protein kinase C (PK-C) binding affinity of σ-lactones Bioorg Med Chem Lett 4:2405-2410 (1994)    Article
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha
Type:
Enzyme
Mol. Mass.:
76842.76
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
672
Sequence:
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRLSEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
  
Inhibitor
Name:
BDBM50281846
Synonyms:
(2R,3R)-2-Hydroxymethyl-5-oxo-4-tridec-(E)-ylidene-tetrahydro-furan-3-carboxylic acid methyl ester | Acetic acid (2S,3R)-2-hydroxymethyl-5-oxo-4-tetradecylidene-tetrahydro-furan-3-yl ester | CHEMBL422215
Type:
Small organic molecule
Emp. Form.:
C21H36O5
Mol. Mass.:
368.5075
SMILES:
CCCCCCCCCCCCC\C=C1\[C@@H](OC(C)=O)[C@H](CO)OC1=O
Structure:
Search PDB for entries with ligand similarity: