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Target
Myelin-associated glycoprotein
Ligand
BDBM50274303
Substrate
n/a
Meas. Tech.
ChEMBL_727029 (CHEMBL1686889)
IC50
37400±n/a nM
Citation
 Abdu-Allah, HH; Watanabe, K; Completo, GC; Sadagopan, M; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Paulson, JC; Tsubata, T; Ando, H; Ishida, H; Kiso, M CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold. Bioorg Med Chem 19:1966-71 (2011) [PubMed]  Article
Target
Name:
Myelin-associated glycoprotein
Synonyms:
GMA | MAG | MAG_HUMAN
Type:
PROTEIN
Mol. Mass.:
69048.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_770764
Residue:
626
Sequence:
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
  
Inhibitor
Name:
BDBM50274303
Synonyms:
CHEMBL502862 | p-Methoxyphenyl (3,5,9-trideoxy-5-glycolamido-9-(4-hydroxy-4-biphenyl)-methylamino-D-glycero-alpha-D-galacto-2-nonulopyranosylonicacid)-(2->6)-beta-D-galactopyranoside
Type:
Small organic molecule
Emp. Form.:
C37H46N2O16
Mol. Mass.:
774.7649
SMILES:
COc1ccc(O[C@@H]2O[C@H](CO[C@@]3(C[C@H](O)[C@@H](NC(=O)CO)[C@@H](O3)[C@H](O)[C@H](O)CNCc3ccc(cc3)-c3ccc(O)cc3)C(O)=O)[C@H](O)[C@H](O)[C@H]2O)cc1 |r|
Structure:
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