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Target
Myelin-associated glycoprotein
Ligand
BDBM50354049
Substrate
n/a
Meas. Tech.
ChEMBL_770762 (CHEMBL1837432)
IC50
300±n/a nM
Citation
 Zeng, Y; Rademacher, C; Nycholat, CM; Futakawa, S; Lemme, K; Ernst, B; Paulson, JC High affinity sialoside ligands of myelin associated glycoprotein. Bioorg Med Chem Lett 21:5045-9 (2011) [PubMed]  Article
Target
Name:
Myelin-associated glycoprotein
Synonyms:
GMA | MAG | MAG_HUMAN
Type:
PROTEIN
Mol. Mass.:
69048.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_770764
Residue:
626
Sequence:
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
  
Inhibitor
Name:
BDBM50354049
Synonyms:
CHEMBL1836306
Type:
Small organic molecule
Emp. Form.:
C40H64N4O29
Mol. Mass.:
1064.9467
SMILES:
C[C@@H](O[C@H]1O[C@H](CO[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O2)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]2O)[C@H]1NC(C)=O)[C@H](N)C(O)=O |r|
Structure:
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