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Target
Myelin-associated glycoprotein
Ligand
BDBM50354051
Substrate
n/a
Meas. Tech.
ChEMBL_770762 (CHEMBL1837432)
IC50
52000±n/a nM
Citation
 Zeng, Y; Rademacher, C; Nycholat, CM; Futakawa, S; Lemme, K; Ernst, B; Paulson, JC High affinity sialoside ligands of myelin associated glycoprotein. Bioorg Med Chem Lett 21:5045-9 (2011) [PubMed]  Article
Target
Name:
Myelin-associated glycoprotein
Synonyms:
GMA | MAG | MAG_HUMAN
Type:
PROTEIN
Mol. Mass.:
69048.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_770764
Residue:
626
Sequence:
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
  
Inhibitor
Name:
BDBM50354051
Synonyms:
CHEMBL1836309
Type:
Small organic molecule
Emp. Form.:
C32H47N2O19
Mol. Mass.:
763.7181
SMILES:
CC(=O)N[C@@H]1[C@@H](O)C[C@@](O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]3[C@@H](O)[C@@H](CO)O[C@H](OCc4ccccc4)[C@@H]3NC(C)=O)[C@@H]2O)(O[C@H]1[C@H](O)[C@H](O)CO)C([O-])=O |r|
Structure:
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