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Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM50364113
Substrate
n/a
Meas. Tech.
ChEMBL_803806 (CHEMBL1954201)
IC50
3±n/a nM
Citation
 Brand, S; Cleghorn, LA; McElroy, SP; Robinson, DA; Smith, VC; Hallyburton, I; Harrison, JR; Norcross, NR; Spinks, D; Bayliss, T; Norval, S; Stojanovski, L; Torrie, LS; Frearson, JA; Brenk, R; Fairlamb, AH; Ferguson, MA; Read, KD; Wyatt, PG; Gilbert, IH Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J Med Chem 55:140-52 (2012) [PubMed]  Article
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50364113
Synonyms:
CHEMBL1230468
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2N6O2S
Mol. Mass.:
495.425
SMILES:
Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Structure:
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