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Target
Glutamate--cysteine ligase catalytic subunit
Ligand
BDBM50366433
Substrate
n/a
Meas. Tech.
ChEBML_68754
Ki
49300±n/a nM
Citation
 Katoh, M; Hiratake, J; Kato, H; Oda, J Mechanism-based inactivation of E. coli -glutamylcysteine synthetase by phosphinic acid- and sulfoximine-based transition-state analogues Bioorg Med Chem Lett 6:1437-1442 (1996)    Article
Target
Name:
Glutamate--cysteine ligase catalytic subunit
Synonyms:
GCLC | GLCL | GLCLC | GSH1_HUMAN | Gamma-glutamylcysteine synthetase
Type:
PROTEIN
Mol. Mass.:
72759.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_68753
Residue:
637
Sequence:
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN
  
Inhibitor
Name:
BDBM50366433
Synonyms:
CHEMBL1609891
Type:
Small organic molecule
Emp. Form.:
C8H16N2O3S
Mol. Mass.:
220.289
SMILES:
CCCCS(=N)(=O)CCC(=N)C(O)=O
Structure:
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