Reaction Details  Report a problem with these data
Target
Kynureninase
Ligand
BDBM50288255
Substrate
n/a
Meas. Tech.
ChEBML_91720
Ki
4280±n/a nM
Citation
 Ross, FC; Botting, NP; Leeson, PD Synthesis of phosphinic acid transition state analogues for the reaction catalysed by kynureninase Bioorg Med Chem Lett 6:2643-2646 (1996)    Article
Target
Name:
Kynureninase
Synonyms:
KYNU | KYNU_HUMAN | L-kynurenine hydrolase
Type:
PROTEIN
Mol. Mass.:
52356.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_91729
Residue:
465
Sequence:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
  
Inhibitor
Name:
BDBM50288255
Synonyms:
2-ammonio-4-(2-ammoniophenyl)-4-oxo-(2S)-butanoate
Type:
Small organic molecule
Emp. Form.:
C10H13N2O3
Mol. Mass.:
209.2213
SMILES:
[NH3+][C@@H](CC(=O)c1ccccc1[NH3+])C([O-])=O
Structure:
Search PDB for entries with ligand similarity: