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Target
Glutamine--tRNA ligase
Ligand
BDBM50290174
Substrate
n/a
Meas. Tech.
ChEBML_72305
Ki
230000±n/a nM
Citation
 Desjardins, M; Desgagnes, J; Lacoste, L; Yang, F; Morin, M; Lapointe, J; Chenevert, R Synthesis of inhibitors of glutamyl-tRNA synthetase Bioorg Med Chem Lett 7:2363-2366 (1997)    Article
Target
Name:
Glutamine--tRNA ligase
Synonyms:
Glutaminyl-tRNA synthetase | QARS | QARS1 | SYQ_HUMAN
Type:
PROTEIN
Mol. Mass.:
87806.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_72305
Residue:
775
Sequence:
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLASRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPEQIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPKLEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVESLEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASLHVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV
  
Inhibitor
Name:
BDBM50290174
Synonyms:
4-ammonio-5-{[(2R,6S)-6-(hydroxymethyl)piperidin-2-yl]methoxy}-5-oxopentanoate | CHEMBL75863
Type:
Small organic molecule
Emp. Form.:
C12H22N2O5
Mol. Mass.:
274.3135
SMILES:
[NH3+]C(CCC([O-])=O)C(=O)OC[C@H]1CCC[C@@H](CO)N1
Structure:
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