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Target
Protein kinase C alpha type
Ligand
BDBM50100121
Substrate
n/a
Meas. Tech.
ChEMBL_153127 (CHEMBL759066)
Ki
330±n/a nM
Citation
Nacro, K; Sigano, DM; Yan, S; Nicklaus, MC; Pearce, LL; Lewin, NE; Garfield, SH; Blumberg, PM; Marquez, VE An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P). J Med Chem 44:1892-904 (2001) [PubMed]
More Info.:
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha
Type:
Enzyme
Mol. Mass.:
76842.76
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
672
Sequence:
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRLSEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
Inhibitor
Name:
BDBM50100121
Synonyms:
3-Isopropyl-4-methyl-pent-2-enoic acid 1-hydroxymethyl-2-(3-methyl-butyryloxy)-ethyl ester | CHEMBL40602
Type:
Small organic molecule
Emp. Form.:
C17H30O5
Mol. Mass.:
314.4171
SMILES:
[#6]-[#6](-[#6])-[#6]-[#6](=O)-[#8]-[#6]-[#6@H](-[#6]-[#8])-[#8]-[#6](=O)\[#6]=[#6](\[#6](-[#6])-[#6])-[#6](-[#6])-[#6]