Reaction Details  Report a problem with these data
Target
Interleukin-2 receptor subunit alpha
Ligand
BDBM50147993
Substrate
n/a
Meas. Tech.
ChEMBL_89084 (CHEMBL878448)
IC50
150000±n/a nM
Citation
 Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem 47:3111-30 (2004) [PubMed]  Article
Target
Name:
Interleukin-2 receptor subunit alpha
Synonyms:
CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55
Type:
PROTEIN
Mol. Mass.:
30733.96
Organism:
Mus musculus
Description:
ChEMBL_89085
Residue:
268
Sequence:
MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKELVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGHCREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTCVDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVASCLFLLISILLLSGLTWQHRWRKSRRTI
  
Inhibitor
Name:
BDBM50147993
Synonyms:
2-Cyclohexyl-N-{2-[4-(2',4'-dichloro-biphenyl-3-yl)-piperidin-1-yl]-2-oxo-ethyl}-2-guanidino-acetamide | CHEMBL105518
Type:
Small organic molecule
Emp. Form.:
C28H35Cl2N5O2
Mol. Mass.:
544.516
SMILES:
[#7]\[#6](-[#7])=[#7]/[#6@H](-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6]-1)-c1cccc(c1)-c1ccc(Cl)cc1Cl
Structure:
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