Reaction Details Report a problem with these data
Target
Insulin receptor
Ligand
BDBM50253182
Substrate
n/a
Meas. Tech.
ChEMBL_538724 (CHEMBL1035035)
EC50
40000±n/a nM
Citation
Lum, RT; Cheng, M; Cristobal, CP; Goldfine, ID; Evans, JL; Keck, JG; Macsata, RW; Manchem, VP; Matsumoto, Y; Park, SJ; Rao, SS; Robinson, L; Shi, S; Spevak, WR; Schow, SR Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators. J Med Chem 51:6173-87 (2008) [PubMed] Article
More Info.:
Target
Name:
Insulin receptor
Synonyms:
CD_antigen=CD220 | INSR_MOUSE | IR | Insr | Insulin receptor subunit alpha | Insulin receptor subunit beta
Type:
PROTEIN
Mol. Mass.:
155593.32
Organism:
Mus musculus
Description:
ChEMBL_305383
Residue:
1372
Sequence:
MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS
Inhibitor
Name:
BDBM50253182
Synonyms:
5-{7-[({7-[(3-carboxy-4-nitrophenyl)sulfamoyl]naphthalen-2-yl}carbamoyl)amino]naphthalene-2-sulfonamido}-2-nitrobenzoic acid | CHEMBL448205
Type:
Small organic molecule
Emp. Form.:
C35H24N6O13S2
Mol. Mass.:
800.727
SMILES:
OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(c(c4)C(O)=O)[N+]([O-])=O)cc3c2)ccc1[N+]([O-])=O