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Target
Disks large homolog 4
Ligand
BDBM50339557
Substrate
n/a
Meas. Tech.
ChEMBL_736707 (CHEMBL1695088)
Ki
4200±n/a nM
Citation
 Bach, A; Eildal, JN; Stuhr-Hansen, N; Deeskamp, R; Gottschalk, M; Pedersen, SW; Kristensen, AS; Strømgaard, K Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem 54:1333-46 (2011) [PubMed]  Article
Target
Name:
Disks large homolog 4
Synonyms:
DLG4 | DLG4_HUMAN | PSD95
Type:
PROTEIN
Mol. Mass.:
80483.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_736705
Residue:
724
Sequence:
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
  
Inhibitor
Name:
BDBM50339557
Synonyms:
(2S,5S,8S,11S)-11-(2-carboxyethyl)-8-((R)-1-hydroxyethyl)-2-isopropyl-5-methyl-4,7,10-trioxo-15-(2,3,4-trifluorophenyl)-3,6,9,12-tetraazapentadecan-1-oic acid | CHEMBL1688621
Type:
Small organic molecule
Emp. Form.:
C26H37F3N4O8
Mol. Mass.:
590.5892
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NCCCc1ccc(F)c(F)c1F)[C@@H](C)O)C(O)=O |r|
Structure:
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