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Target
Signal transducer and activator of transcription 6
Ligand
BDBM50401025
Substrate
n/a
Meas. Tech.
ChEMBL_881438 (CHEMBL2214425)
Kd
73970±n/a nM
Citation
 Zhou, L; Kawate, T; Liu, X; Kim, YB; Zhao, Y; Feng, G; Banerji, J; Nash, H; Whitehurst, C; Jindal, S; Siddiqui, A; Seed, B; Wolfe, JL STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg Med Chem 20:750-8 (2012) [PubMed]  Article
Target
Name:
Signal transducer and activator of transcription 6
Synonyms:
STAT6 | STAT6_HUMAN
Type:
PROTEIN
Mol. Mass.:
94129.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881634
Residue:
847
Sequence:
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
  
Inhibitor
Name:
BDBM50401025
Synonyms:
CHEMBL2203687
Type:
Small organic molecule
Emp. Form.:
C18H20N2O2S
Mol. Mass.:
328.429
SMILES:
CN(CCc1ccccc1)C(=O)c1csc2C(CCCc12)N=O
Structure:
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