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Target
P2X purinoceptor 6
Ligand
BDBM50415550
Substrate
n/a
Meas. Tech.
ChEMBL_612726 (CHEMBL1069598)
IC50
>10000±n/a nM
Citation
 Brotherton-Pleiss, CE; Dillon, MP; Ford, AP; Gever, JR; Carter, DS; Gleason, SK; Lin, CJ; Moore, AG; Thompson, AW; Villa, M; Zhai, Y Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett 20:1031-6 (2010) [PubMed]  Article
Target
Name:
P2X purinoceptor 6
Synonyms:
ATP receptor | P2RX6 | P2RX6_HUMAN | P2RXL1 | P2X6 | P2XM | Purinergic receptor | Purinergic receptor P2X-like 1
Type:
PROTEIN
Mol. Mass.:
48834.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_612726
Residue:
441
Sequence:
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPGWPCPSSDTHLPTHSGSL
  
Inhibitor
Name:
BDBM50415550
Synonyms:
CHEMBL599760 | Ro-85
Type:
Small organic molecule
Emp. Form.:
C22H27N5O2S
Mol. Mass.:
425.547
SMILES:
C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 |r|
Structure:
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