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Target
Mitogen-activated protein kinase 13
Ligand
BDBM50420748
Substrate
n/a
Meas. Tech.
ChEMBL_842608 (CHEMBL2092446)
IC50
49±n/a nM
Citation
 Aiguadé, J; Balagué, C; Carranco, I; Caturla, F; Domínguez, M; Eastwood, P; Esteve, C; González, J; Lumeras, W; Orellana, A; Preciado, S; Roca, R; Vidal, L; Vidal, B Novel triazolopyridylbenzamides as potent and selective p38a inhibitors. Bioorg Med Chem Lett 22:3431-6 (2012) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 13
Synonyms:
MAP kinase p38 delta | MAPK13 | MK13_HUMAN | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase 13 (MAPK13) | Mitogen-activated protein kinase p38 | Mitogen-activated protein kinase p38 delta | PRKM13 | SAPK4 | Stress-activated protein kinase 4 | p38 delta/gamma
Type:
Enzyme
Mol. Mass.:
42097.16
Organism:
Homo sapiens (Human)
Description:
O15264
Residue:
365
Sequence:
MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMKL
  
Inhibitor
Name:
BDBM50420748
Synonyms:
CHEMBL2087741
Type:
Small organic molecule
Emp. Form.:
C21H22F2N4O
Mol. Mass.:
384.4224
SMILES:
Cc1ccc(cc1-c1c(F)cn2c(nnc2c1F)C(C)(C)C)C(=O)NC1CC1 |(17.76,-16.42,;19.09,-15.65,;19.09,-14.11,;20.42,-13.34,;21.76,-14.1,;21.76,-15.65,;20.42,-16.42,;20.42,-17.96,;21.75,-18.72,;23.08,-17.96,;21.74,-20.27,;20.41,-21.04,;20.08,-22.54,;18.55,-22.69,;17.93,-21.28,;19.08,-20.26,;19.08,-18.73,;17.75,-17.95,;20.88,-23.84,;20.16,-25.2,;22.42,-23.79,;21.65,-25.16,;23.09,-13.33,;23.08,-11.79,;24.42,-14.09,;25.75,-13.32,;27.29,-13.32,;26.52,-11.99,)|
Structure:
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