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Target
Sodium/iodide cotransporter
Ligand
BDBM50430685
Substrate
n/a
Meas. Tech.
ChEMBL_942514 (CHEMBL2346169)
IC50
0.850000±n/a nM
Citation
 Lacotte, P; Buisson, DA; Ambroise, Y Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors. Eur J Med Chem 62:722-7 (2013) [PubMed]  Article
Target
Name:
Sodium/iodide cotransporter
Synonyms:
Na(+)/I(-) cotransporter | Na(+)/I(-) symporter | Nis | SC5A5_RAT | Slc5a5 | Sodium-iodide symporter | Solute carrier family 5 member 5
Type:
PROTEIN
Mol. Mass.:
65197.60
Organism:
Rattus norvegicus
Description:
ChEMBL_942514
Residue:
618
Sequence:
MEGAEAGARATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTATLEESLVKGPEDIPAVTKKPPGLKPGAETHPLYLGHDVETNL
  
Inhibitor
Name:
BDBM50430685
Synonyms:
CHEMBL2333509
Type:
Small organic molecule
Emp. Form.:
C20H20N2O6
Mol. Mass.:
384.3826
SMILES:
CN1[C@H](c2ccco2)C(C(=O)OCc2ccc3OCOc3c2)=C(C)N(C)C1=O |r,t:24|
Structure:
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