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Target
Histamine receptor H3
Ligand
BDBM50434387
Substrate
n/a
Meas. Tech.
ChEMBL_961066 (CHEMBL2389497)
Ki
7.1±n/a nM
Citation
 Gao, Z; Hurst, WJ; Guillot, E; Czechtizky, W; Lukasczyk, U; Nagorny, R; Pruniaux, MP; Schwink, L; Sanchez, JA; Stengelin, S; Tang, L; Winkler, I; Hendrix, JA; George, PG Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I). Bioorg Med Chem Lett 23:3416-20 (2013) [PubMed]  Article
Target
Name:
Histamine receptor H3
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
48611.84
Organism:
Macaca mulatta (Rhesus macaque)
Description:
Q865E1
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM50434387
Synonyms:
CHEMBL2387290
Type:
Small organic molecule
Emp. Form.:
C23H28Cl2N4O
Mol. Mass.:
447.401
SMILES:
CC1CCCN1C1CCN(C1)c1ccc(NC(=O)NCc2cc(Cl)cc(Cl)c2)cc1
Structure:
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