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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50019143
Substrate
n/a
Meas. Tech.
ChEMBL_1361815 (CHEMBL3292751)
IC50
400±n/a nM
Citation
 Fu, HJ; Zhou, YR; Bao, BH; Jia, MX; Zhao, Y; Zhang, L; Li, JX; He, HL; Zhou, XM Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. J Med Chem 57:4692-709 (2014) [PubMed]  Article
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH1_RAT | Tph | Tph1 | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
51069.51
Organism:
Rattus norvegicus
Description:
ChEMBL_1361815
Residue:
444
Sequence:
MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV
  
Inhibitor
Name:
BDBM50019143
Synonyms:
CHEMBL511275 | US10683309, Example LP533401
Type:
Small organic molecule
Emp. Form.:
C27H22F4N4O3
Mol. Mass.:
526.4822
SMILES:
N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccc(cc2)-c2cccc(F)c2)C(F)(F)F)nc(N)n1)C(O)=O |r|
Structure:
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