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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50040259
Substrate
n/a
Meas. Tech.
ChEMBL_1443754 (CHEMBL3371727)
Ki
87±n/a nM
Citation
 Xu, R; Lord, SA; Peterson, RM; Fergason-Cantrell, EA; Lever, JR; Lever, SZ Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters. Bioorg Med Chem 23:222-30 (2014) [PubMed]  Article
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Dat | Dat1 | Dopamine transporter | SC6A3_MOUSE | Slc6a3 | Sodium-dependent dopamine transporter | Solute carrier family 6 member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68809.06
Organism:
MOUSE
Description:
Dopamine Transporter SLC6A3 MOUSE::Q61327
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDRQLVDRGEVRQFTLRHWLLV
  
Inhibitor
Name:
BDBM50040259
Synonyms:
CHEMBL3360025
Type:
Small organic molecule
Emp. Form.:
C31H40N2O2
Mol. Mass.:
472.6615
SMILES:
COc1cc(CCN2CCN(CCCc3ccccc3)CC2)ccc1OCCCc1ccccc1
Structure:
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