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Target
Ubiquitin carboxyl-terminal hydrolase 2
Ligand
BDBM50072959
Substrate
n/a
Meas. Tech.
ChEMBL_1467810 (CHEMBL3412535)
IC50
32560±n/a nM
Citation
 Cersosimo, U; Sgorbissa, A; Foti, C; Drioli, S; Angelica, R; Tomasella, A; Picco, R; Semrau, MS; Storici, P; Benedetti, F; Berti, F; Brancolini, C Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent. J Med Chem 58:1691-704 (2015) [PubMed]  Article
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 2
Synonyms:
41 kDa ubiquitin-specific protease | Deubiquitinating enzyme 2 | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin thioesterase 2 | Ubiquitin-specific-processing protease 2
Type:
PROTEIN
Mol. Mass.:
68093.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103660
Residue:
605
Sequence:
MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
  
Inhibitor
Name:
BDBM50072959
Synonyms:
CHEMBL3410535
Type:
Small organic molecule
Emp. Form.:
C19H14N2O7S
Mol. Mass.:
414.389
SMILES:
[O-][N+](=O)c1ccc(\C=C2/CS(=O)(=O)C\C(=C/c3ccc(cc3)[N+]([O-])=O)C2=O)cc1
Structure:
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