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Target
Histone acetyltransferase GCN5
Ligand
BDBM50076432
Substrate
n/a
Meas. Tech.
ChEMBL_1473961 (CHEMBL3419557)
IC50
1200±n/a nM
Citation
 Dahlin, JL; Nissink, JW; Strasser, JM; Francis, S; Higgins, L; Zhou, H; Zhang, Z; Walters, MA PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. J Med Chem 58:2091-113 (2015) [PubMed]  Article
Target
Name:
Histone acetyltransferase GCN5
Synonyms:
ADA4 | ADA4 | GCN5 | GCN5_YEAST | Histone acetyltransferase GCN5 | SWI9
Type:
PROTEIN
Mol. Mass.:
51069.24
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_100832
Residue:
439
Sequence:
MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETERIGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNIKPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEEVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID
  
Inhibitor
Name:
BDBM50076432
Synonyms:
CHEMBL3416526
Type:
Small organic molecule
Emp. Form.:
C19H15ClN4O3S
Mol. Mass.:
414.865
SMILES:
COc1ccc(cc1)-c1nnc(SC2CC(=O)N(C2=O)c2ccc(Cl)cc2)[nH]1
Structure:
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