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Target
Histone acetyltransferase GCN5
Ligand
BDBM50420797
Substrate
n/a
Meas. Tech.
ChEMBL_1473963 (CHEMBL3419559)
IC50
2500±n/a nM
Citation
 Dahlin, JL; Nissink, JW; Strasser, JM; Francis, S; Higgins, L; Zhou, H; Zhang, Z; Walters, MA PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. J Med Chem 58:2091-113 (2015) [PubMed]  Article
Target
Name:
Histone acetyltransferase GCN5
Synonyms:
ADA4 | ADA4 | GCN5 | GCN5_YEAST | Histone acetyltransferase GCN5 | SWI9
Type:
PROTEIN
Mol. Mass.:
51069.24
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_100832
Residue:
439
Sequence:
MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETERIGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNIKPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEEVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID
  
Inhibitor
Name:
BDBM50420797
Synonyms:
CHEMBL2030281
Type:
Small organic molecule
Emp. Form.:
C22H16N4O3S2
Mol. Mass.:
448.517
SMILES:
Oc1c(Sc2nnc[nH]2)cc(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc12
Structure:
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