Reaction Details  Report a problem with these data
Target
Hydroxyacylglutathione hydrolase, mitochondrial
Ligand
BDBM50092824
Substrate
n/a
Meas. Tech.
ChEMBL_1524149 (CHEMBL3631234)
Ki
1700±n/a nM
Citation
 Sang, Y; Shi, Q; Mo, M; Ni, C; Li, Z; Liu, B; Deng, Q; Creighton, DJ; Zheng, ZB Novel bivalent inhibitors with sub-nanomolar affinities towards human glyoxalase I. Bioorg Med Chem Lett 25:4724-7 (2015) [PubMed]  Article
Target
Name:
Hydroxyacylglutathione hydrolase, mitochondrial
Synonyms:
GLO2_BOVIN | Glx II | Glyoxalase II | HAGH | Hydroxyacylglutathione hydrolase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
34097.41
Organism:
Bos taurus
Description:
ChEMBL_109913
Residue:
308
Sequence:
MVLGRGLLGRWSVAELGAVCARLGLGPALLGSLHHLGLRKSLTVDQGTMKVELLPALTDNYMYLLIDEDTKEAAIVDPVQPQKVVETARKHGVKLTTVLTTHHHWDHAGGNEKLVKLEPGLKVYGGDDRIGALTHKVTHLSTLQVGSLHVKCLSTPCHTSGHICYFVTKPNSPEPPAVFTGDTLFVAGCGKFYEGTADEMYKALLEVLGRLPADTRVYCGHEYTINNLKFARHVEPDNTAVREKLAWAKEKYSIGEPTVPSTIAEEFTYNPFMRVREKTVQQHAGETEPVATMRAIRKEKDQFKMPRD
  
Inhibitor
Name:
BDBM50092824
Synonyms:
CHEMBL131578 | S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione
Type:
Small organic molecule
Emp. Form.:
C17H21ClN4O8S
Mol. Mass.:
476.889
SMILES:
N[C@@H](CCC(=O)N[C@@H](CSC(=O)N(O)c1ccc(Cl)cc1)C(=O)NCC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: