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Target
Serine/threonine-protein phosphatase 2A activator
Ligand
BDBM50222936
Substrate
n/a
Meas. Tech.
ChEMBL_161792 (CHEMBL768166)
IC50
<10000±n/a nM
Citation
 Souto, ML; Manríquez, CP; Norte, M; Leira, F; Fernández, JJ The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. Bioorg Med Chem Lett 13:1261-4 (2003) [PubMed]
Target
Name:
Serine/threonine-protein phosphatase 2A activator
Synonyms:
5.2.1.8 | PPP2R4 | PTPA | PTPA_HUMAN | Phosphotyrosyl phosphatase activator | Protein phosphatase 2A regulatory subunit B | Protein phosphatase 2A regulatory subunit B' | Serine/threonine-protein phosphatase 2A activator | Serine/threonine-protein phosphatase 2A regulatory subunit 4
Type:
n/a
Mol. Mass.:
40662.53
Organism:
Homo sapiens (Human)
Description:
Q15257
Residue:
358
Sequence:
MAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
  
Inhibitor
Name:
BDBM50222936
Synonyms:
CHEMBL18962
Type:
Small organic molecule
Emp. Form.:
C30H51BrO7
Mol. Mass.:
603.626
SMILES:
[H][C@](O)(C[C@H](O)[C@@]1(C)CC[C@@]([H])(O1)C(C)(C)O)C(=C)[C@@]1([H])CC[C@@]2([H])O[C@]([H])(CC[C@]2(C)O1)[C@]1(C)CC[C@@H](Br)C(C)(C)O1
Structure:
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