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Target
Dual specificity mitogen-activated protein kinase kinase 6
Ligand
BDBM50413752
Substrate
n/a
Meas. Tech.
ChEMBL_1649690 (CHEMBL3998824)
IC50
388±n/a nM
Citation
 Cho, H; Sengupta, S; Jeon, SS; Hur, W; Choi, HG; Seo, HS; Lee, BJ; Kim, JH; Chung, M; Jeon, NL; Kim, ND; Sim, T Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277. J Med Chem 60:1495-1508 (2017) [PubMed]  Article
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 6
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3
Type:
Protein
Mol. Mass.:
37494.96
Organism:
Homo sapiens (Human)
Description:
P52564
Residue:
334
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
  
Inhibitor
Name:
BDBM50413752
Synonyms:
CHEMBL2012519 | L-783277
Type:
Small organic molecule
Emp. Form.:
C19H24O7
Mol. Mass.:
364.3897
SMILES:
COc1cc(O)c2c(CCCC(=O)C(=O)C(O)CCC[C@H](C)OC2=O)c1 |r|
Structure:
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