Reaction Details  Report a problem with these data
Target
Vitamin K epoxide reductase complex subunit 1
Ligand
BDBM50235668
Substrate
n/a
Meas. Tech.
ChEMBL_1657647 (CHEMBL4007117)
Ki
50±n/a nM
Citation
 Montagut-Romans, A; Boulven, M; Jacolot, M; Moebs-Sanchez, S; Hascoët, C; Hammed, A; Besse, S; Lemaire, M; Benoit, E; Lattard, V; Popowycz, F Synthesis and biological evaluation of C-3 aliphatic coumarins as vitamin K antagonists. Bioorg Med Chem Lett 27:1598-1601 (2017) [PubMed]  Article
Target
Name:
Vitamin K epoxide reductase complex subunit 1
Synonyms:
VKOR1_RAT | Vitamin K epoxide reductase complex subunit 1 (rVKORC1) | Vkorc1
Type:
Enzyme
Mol. Mass.:
17793.51
Organism:
Rattus norvegicus (Rat)
Description:
Q6TEK4
Residue:
161
Sequence:
MGTTWRSPGRLRLALCLAGLALSLYALHVKAARARNEDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGADSILNQSNSIFGCMFYTIQLLLGCLRGRWASILLILSSLVSVAGSLYLAWILFFVLYDFCIVCITTYAINAGLMLLSFQKVPEHKVKKP
  
Inhibitor
Name:
BDBM50235668
Synonyms:
CHEMBL4098946
Type:
Small organic molecule
Emp. Form.:
C29H46O3
Mol. Mass.:
442.6737
SMILES:
CC(C)CCCC(C)CCCC(C)CCCC(C)CCc1c(O)c2ccccc2oc1=O
Structure:
Search PDB for entries with ligand similarity: