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Target
Secreted chorismate mutase
Ligand
BDBM108069
Substrate
n/a
Meas. Tech.
CM Assay
Temperature
310.15±n/a K
IC50
6.690e+4± 5.80e+3 nM
Comments
extracted
Citation
 Jeankumar, VU; Alokam, R; Sridevi, JP; Suryadevara, P; Matikonda, SS; Peddi, S; Sahithi, S; Alvala, M; Yogeeswari, P; Sriram, D Discovery and Structure Optimization of a Series of Isatin Derivatives as Mycobacterium tuberculosis Chorismate Mutase Inhibitors. Chem Biol Drug Des 83:498-506 (2014) [PubMed]  Article
Target
Name:
Secreted chorismate mutase
Synonyms:
Chorismate mutase (CM) | Chorismate mutase (MTB CM) | Chorismate mutase-related protein | SCMU_MYCTU
Type:
Protein
Mol. Mass.:
21942.03
Organism:
Mycobacterium tuberculosis H37Rv
Description:
n/a
Residue:
199
Sequence:
MLTRPREIYLATAVSIGILLSLIAPLGPPLARADGTSQLAELVDAAAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDARSQHIDPDYVTRVFDDQIRATEAIEYSRFSDWKLNPASAPPEPPDLSASRSAIDSLNNRMLSQIWSHWSLLSAPSCAAQLDRAKRDIVRSRHLDSLYQRALTTATQSYCQALPPA
  
Inhibitor
Name:
BDBM108069
Synonyms:
3‐amino‐1‐[(3Z)‐2‐oxo‐1H‐indol‐3‐ylidene]thiourea (Compound 9)
Type:
Small organic molecule
Emp. Form.:
C9H8N4OS
Mol. Mass.:
220.251
SMILES:
NNC(=S)N=C1C(=O)Nc2ccccc12 |w:4.3|
Structure:
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