Reaction Details  Report a problem with these data
Target
Dopa decarboxylase (Aromatic L-amino acid decarboxylase), isoform CRA_a
Ligand
BDBM112633
Substrate
n/a
Meas. Tech.
DDC-MDH-PEPC-Linked assay
pH
8.05±n/a
Temperature
310.15±n/a K
IC50
2.16e+4± 2.7e+3 nM
Comments
extracted
Citation
 Ren, J; Zhang, Y; Jin, H; Yu, J; Zhou, Y; Wu, F; Zhang, W Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb. ACS Chem Biol 9:897-903 (2014) [PubMed]  Article
Target
Name:
Dopa decarboxylase (Aromatic L-amino acid decarboxylase), isoform CRA_a
Synonyms:
Aromatic-L-amino-acid decarboxylase | DDC | DOPA decarboxylase (DDC)
Type:
Protein
Mol. Mass.:
53899.74
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
480
Sequence:
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
  
Inhibitor
Name:
BDBM112633
Synonyms:
Combrequinone B (6)
Type:
Small organic molecule
Emp. Form.:
C34H36O9
Mol. Mass.:
588.6442
SMILES:
COc1cc(CCCc2cc(C(=CCc3ccc(O)c(OC)c3)c3cc(O)c(OC)cc3O)c(OC)cc2O)ccc1O |w:12.12|
Structure:
Search PDB for entries with ligand similarity: