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Target
Epoxide hydrolase 1
Ligand
BDBM129295
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
50±n/a nM
Citation
 Hammock, BD; Zheng, J; Morisseau, C; Motoba, K; Moghaddam, MF; Borhan, B; Grant, DF; Greene, J; Sisemore, MF; Sanborn, J Inhibitors of epoxide hydrolases for the treatment of inflammation US Patent  US8815951 Publication Date 8/26/2014
Target
Name:
Epoxide hydrolase 1
Synonyms:
Ephx1 | Epoxide hydrolase (HsEH) | Epoxide hydrolase (MsEH) | HYEP_MOUSE
Type:
Protein
Mol. Mass.:
52586.43
Organism:
Mus musculus (Mouse)
Description:
Q9D379
Residue:
455
Sequence:
MWLELILASVLGFVIYWFVSRDKEETLPLEDGWWGPGSKPSAKEDESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSSYLKKVVSFWRNEFDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKTHGLSDEHVFEVICPSIPGYGFSEASSKKGLNSVATARIFYKLMSRLGFQKFYIQGGDWGSLICTNIAQMVPNHVKGLHLNMSFISRNIYSLTPLLGQRFGRFLGYTEKDLELLYPFKEKVFYNIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLEDLLTNIMIYWTTGTIVSSQRFYKENLGQGVMVHRHEGMKVFVPTGYSAFPSEILHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAELQ
  
Inhibitor
Name:
BDBM129295
Synonyms:
US8815951, 140
Type:
Small organic molecule
Emp. Form.:
C19H22N2O2
Mol. Mass.:
310.3902
SMILES:
O=C(NC1CCCCC1)Nc1ccc(Oc2ccccc2)cc1
Structure:
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