Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM141351
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.23±n/a nM
Citation
 Hayashi, K; Tamura, Y; Omori, N 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity US Patent  US8916594 Publication Date 12/23/2014
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM141351
Synonyms:
US8916594, I-053
Type:
Small organic molecule
Emp. Form.:
C17H22F2N4O3S
Mol. Mass.:
400.443
SMILES:
CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cc(F)cc(F)c1 |r,wU:7.6,wD:10.13,(-9.5,1.44,;-8.16,.67,;-6.83,1.44,;-7.6,2.77,;-6.06,2.77,;-5.5,.67,;-4.16,1.44,;-2.83,.67,;-1.49,1.44,;-.16,.67,;-.16,-.87,;-1.49,-1.64,;-2.83,-.87,;1.17,-1.64,;2.51,-.87,;3.97,-1.35,;4.88,-.1,;3.97,1.14,;2.51,.67,;6.42,-.1,;7.19,1.23,;8.73,1.23,;9.5,2.56,;9.5,-.1,;8.73,-1.44,;9.5,-2.77,;7.19,-1.44,)|
Structure:
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