Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM141362
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.04±n/a nM
Citation
 Hayashi, K; Tamura, Y; Omori, N 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity US Patent  US8916594 Publication Date 12/23/2014
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM141362
Synonyms:
US8916594, I-149
Type:
Small organic molecule
Emp. Form.:
C15H23F5N4O3S
Mol. Mass.:
434.425
SMILES:
CC(C)(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C(F)(F)C(F)(F)F |r,wU:12.15,wD:9.8,(7.36,6.69,;6.02,5.92,;5.25,7.26,;6.79,4.59,;4.69,5.15,;3.92,6.49,;5.46,3.82,;3.36,4.38,;3.36,2.84,;2.02,2.07,;.69,2.84,;-.65,2.07,;-.65,.53,;.69,-.24,;2.02,.53,;-1.98,-.24,;-1.98,-1.78,;-3.23,-2.68,;-2.75,-4.15,;-1.21,-4.15,;-.73,-2.68,;-3.65,-5.39,;-4.9,-4.49,;-2.41,-6.3,;-4.56,-6.64,;-5.47,-7.89,;-5.81,-5.73,;-3.31,-7.54,)|
Structure:
Search PDB for entries with ligand similarity: