Reaction Details  Report a problem with these data
Target
Acetyltransferase, GNAT family
Ligand
BDBM152706
Substrate
n/a
Meas. Tech.
Eis Ban Inhibition Assay
pH
8±n/a
IC50
1.4e+4± 4e+3 nM
Comments
extracted
Citation
 Green, KD; Biswas, T; Chang, C; Wu, R; Chen, W; Janes, BK; Chalupska, D; Gornicki, P; Hanna, PC; Tsodikov, OV; Joachimiak, A; Garneau-Tsodikova, S Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis. Biochemistry 54:3197-206 (2015) [PubMed]  Article
Target
Name:
Acetyltransferase, GNAT family
Synonyms:
Eis_Ban acetyltransferase (Eis_Ban)
Type:
Protein
Mol. Mass.:
45469.21
Organism:
Bacillus anthracis str. Sterne
Description:
Q81P65
Residue:
385
Sequence:
MNVIRLKEDKFREALRLSEYAFQYKVDEDRLQQQITKMKESHEVYGIMEGENLAAKLHLIPFHIYIGKEKFKMGGVAGVATYPEYRRSGYVKELLQHSLQTMKKDGYTVSMLHPFAVSFYRKYGWELCANLLVCHMTKSDLVMKKQVNGTVKRFNKESHPEEVEKLYETFAELFSGMLVRNEKWWLQAVYDDLTLAIYYDENQTAAGYMLYKIENYKMTVEEFVPLHNEARNGLWNFICQHDSMIKDLEMTVSENEPLLYTLQEPRVKTEIKPYFMGRIVDVEQFLKQYELNWNNVQQEVILHITDSFAQWNNITVRIANHEITIIEEPIDKGIKLDINALSTILFGYRRPLELNELELISGSEEEIRAFESVVPVRKPFIYDFF
  
Inhibitor
Name:
BDBM152706
Synonyms:
Chlorhexidine | Chlorhexidine (1)
Type:
Small organic molecule
Emp. Form.:
C22H30Cl2N10
Mol. Mass.:
505.447
SMILES:
Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
Structure:
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