Reaction Details  Report a problem with these data
Target
Signal transducer and activator of transcription 5A
Ligand
BDBM165192
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
Ki
1.3e+4±7e+2 nM
IC50
26400±1400 nM
Citation
 Elumalai, N; Berg, A; Rubner, S; Berg, T Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b. ACS Chem Biol 10:2884-90 (2015) [PubMed]  Article
Target
Name:
Signal transducer and activator of transcription 5A
Synonyms:
STA5A_HUMAN | STAT5 | STAT5A | Signal transducer and activator of transcription 5A | Transcription factor STAT5a (STAT5a)
Type:
Protein
Mol. Mass.:
90643.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
794
Sequence:
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
  
Inhibitor
Name:
BDBM165192
Synonyms:
4-((8-Methylnonanamido)methyl)-1,2-phenylene bis(dihydrogen phosphate) (6a)
Type:
n/a
Emp. Form.:
C17H29NO9P2
Mol. Mass.:
453.361
SMILES:
CC(C)CCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OP(O)(O)=O)c1
Structure:
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