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Target
Signal transducer and activator of transcription 5B
Ligand
BDBM165193
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
Ki
3.9e+2±3e+1 nM
IC50
860±70 nM
Citation
 Elumalai, N; Berg, A; Rubner, S; Berg, T Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b. ACS Chem Biol 10:2884-90 (2015) [PubMed]  Article
Target
Name:
Signal transducer and activator of transcription 5B
Synonyms:
STA5B_HUMAN | STAT5B | Signal transducer and activator of transcription 5B | Transcription factor STAT5b (STAT5b)
Type:
Protein
Mol. Mass.:
89858.26
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
787
Sequence:
MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
  
Inhibitor
Name:
BDBM165193
Synonyms:
4-(Nonanamidomethyl)-1,2-phenylene bis(dihydrogen phosphate) (6b)
Type:
n/a
Emp. Form.:
C16H27NO9P2
Mol. Mass.:
439.3344
SMILES:
CCCCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OP(O)(O)=O)c1
Structure:
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