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Target
Isoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)
Ligand
BDBM86646
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
IC50
>100000±n/a nM
Citation
 Hoffman, CS; Ceyhan, O Inhibitors of phosphodiesterase 11 (PDE11) US Patent  US9173884 Publication Date 11/3/2015
Target
Name:
Isoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)
Synonyms:
PDE2A | PDE2A_HUMAN | Phosphodiesterase 2A (PDE2A2) | cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)
Type:
Protein
Mol. Mass.:
105121.70
Organism:
Homo sapiens (Human)
Description:
O00408-3
Residue:
934
Sequence:
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
  
Inhibitor
Name:
BDBM86646
Synonyms:
BC11-38-4 | US9173884, BC11-38-4
Type:
Small organic molecule
Emp. Form.:
C16H18N2O2S2
Mol. Mass.:
334.456
SMILES:
CCCSc1nc2CCSc2c(=O)n1-c1ccccc1OC |(5.66,2.64,;4.32,3.41,;2.99,2.64,;1.65,3.41,;.32,2.64,;-1.01,3.41,;-2.35,2.64,;-3.81,3.12,;-4.72,1.87,;-3.81,.62,;-2.35,1.1,;-1.01,.33,;-1.01,-1.21,;.32,1.1,;1.65,.33,;2.99,1.1,;4.32,.33,;4.32,-1.21,;2.99,-1.98,;1.65,-1.21,;.32,-1.98,;.32,-3.52,)|
Structure:
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