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Target
Taste receptor type 2 member 8
Ligand
BDBM211360
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assays
IC50
10.00±n/a nM
Citation
 Karanewsky, DS; Fotsing, JR; Tachdjian, C; Arellano, M Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof US Patent  US9247759 Publication Date 2/2/2016
Target
Name:
Taste receptor type 2 member 8
Synonyms:
T2R8 | TA2R8_HUMAN | TAS2R8 | TRB5 | Taste receptor family B member 5 | Taste receptor type 2 member 8 (T2R8)
Type:
n/a
Mol. Mass.:
35897.08
Organism:
Homo sapiens (Human)
Description:
Q9NYW2
Residue:
309
Sequence:
MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
  
Inhibitor
Name:
BDBM211360
Synonyms:
US9247759, 12-11
Type:
Small organic molecule
Emp. Form.:
C20H21N5O3
Mol. Mass.:
379.4124
SMILES:
C[C@@H]1N(Cc2ccccc2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r|
Structure:
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