Reaction Details  Report a problem with these data
Target
Adenosine 5'-monophosphoramidase HINT1
Ligand
BDBM426056
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
Kd
3650±1000 nM
Citation
 Wagner, CR; Shah, R Sulfamide and sulfamate inhibitors of hHint1 US Patent  US10513520 Publication Date 12/24/2019
Target
Name:
Adenosine 5'-monophosphoramidase HINT1
Synonyms:
Adenosine 5'-monophosphoramidase | HINT | HINT1 | HINT1_HUMAN | Histidine triad nucleotide-binding protein 1 | PKCI-1 | PKCI1 | PRKCNH1 | Protein kinase C inhibitor 1 | Protein kinase C-interacting protein 1
Type:
PROTEIN
Mol. Mass.:
13803.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_795618
Residue:
126
Sequence:
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
  
Inhibitor
Name:
BDBM426056
Synonyms:
US10513520, Compound 3
Type:
Small organic molecule
Emp. Form.:
C21H23N7O6
Mol. Mass.:
469.4506
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COC(=O)NCCc2c[nH]c3ccccc23)C(O)[C@@H]1O |r|
Structure:
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