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Target
Nuclear receptor subfamily 2 group C member 2
Ligand
BDBM439318
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
53.8±n/a nM
Citation
 Treon, SP; Buhrlage, SJ; Gray, NS; Tan, L; Yang, G Methods to treat lymphoplasmacytic lymphoma US Patent  US10633348 Publication Date 4/28/2020
Target
Name:
Nuclear receptor subfamily 2 group C member 2
Synonyms:
NR2C2 | NR2C2_HUMAN | Nuclear receptor subfamily 2 group C member 2 | Nuclear receptor subfamily 2 group C member 2 (TAK1) | TAK1 | TR4
Type:
PROTEIN
Mol. Mass.:
65411.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476357
Residue:
596
Sequence:
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
  
Inhibitor
Name:
BDBM439318
Synonyms:
US10633348, Compound (A-14)
Type:
Small organic molecule
Emp. Form.:
C30H33F3N8O2
Mol. Mass.:
594.6306
SMILES:
CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4ccnc(Nc5cnn(C)c5)n4)c3)cc2C(F)(F)F)CC1
Structure:
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