Found 5 hits for UniProtKB: P0A8T7 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
DNA-directed RNA polymerase subunit beta'
(Escherichia coli K-12) | BDBM43866
(2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,1...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O Show InChI InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| Purchase
DrugBank
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase |
J Med Chem 22: 1051-5 (1979)
BindingDB Entry DOI: 10.7270/Q2SQ91WG |
More data for this
Ligand-Target Pair | |
DNA-directed RNA polymerase subunit beta'
(Escherichia coli K-12) | BDBM50000057
(CHEMBL3228737)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(NCCCNC5CC(C)(C)[N+]([O-])C(C)(C)C5)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |r,wU:12.13,8.111,55.57,50.52,1.0,wD:49.50,76.83,91.98,86.93,68.70,^1:39,(37.15,-26.86,;38.9,-26.18,;37.87,-25.04,;38.62,-23.71,;40.14,-24.02,;40.32,-25.53,;41.66,-26.3,;41.66,-27.84,;42.99,-25.53,;44.32,-26.3,;46.86,-32.42,;48.19,-33.19,;45.52,-33.16,;45.51,-34.7,;46.84,-35.5,;48.17,-34.73,;46.83,-37.04,;45.5,-37.78,;45.48,-39.32,;46.81,-40.12,;46.79,-41.65,;48.14,-39.35,;49.47,-40.12,;50.8,-39.36,;52.11,-40.13,;52.09,-41.68,;53.43,-39.37,;54.77,-40.16,;53.44,-37.85,;54.77,-37.08,;56.11,-37.85,;57.44,-37.08,;58.77,-37.85,;58.77,-39.39,;60.11,-40.16,;60.1,-41.7,;61.43,-42.46,;61.42,-44,;60.09,-43.22,;62.77,-41.7,;64.1,-42.48,;62.77,-40.16,;63.53,-38.82,;64.31,-40.15,;61.43,-39.38,;52.11,-37.08,;52.13,-35.54,;50.8,-34.77,;53.46,-34.77,;53.46,-33.23,;54.81,-32.46,;54.82,-30.94,;56.14,-33.25,;57.48,-32.48,;57.48,-30.95,;58.81,-33.26,;58.8,-34.8,;60.14,-35.57,;57.47,-35.57,;60.15,-32.49,;61.48,-33.27,;60.16,-30.95,;58.82,-30.18,;61.49,-30.19,;61.49,-28.64,;62.84,-27.88,;60.16,-27.87,;58.83,-28.64,;60.18,-26.33,;61.85,-27.2,;61.44,-25.43,;60.95,-23.96,;59.41,-23.96,;58.94,-25.42,;57.59,-26.18,;57.59,-27.73,;56.26,-25.41,;54.93,-26.16,;52.13,-32.46,;50.8,-33.23,;56.26,-23.85,;54.93,-23.08,;57.61,-23.08,;50.8,-37.83,;49.47,-37.06,;48.16,-37.81,;44.19,-32.39,;44.2,-30.85,;42.85,-33.16,;41.52,-32.37,;41.54,-30.83,;40.19,-33.13,;40.16,-34.67,;41.49,-35.45,;38.83,-35.43,;38.85,-32.35,;37.52,-33.11,;38.86,-30.81,;40.21,-30.05,;37.53,-30.03,;37.55,-28.49,;36.22,-27.7,;38.9,-27.73,;40.21,-28.5,;42.96,-23.99,;44.31,-23.22,;41.63,-23.22,)| Show InChI InChI=1S/C74H109N14O17/c1-36(2)51-69(98)86-30-21-24-46(86)67(96)82(17)34-48(89)84(19)58(38(5)6)71(100)103-42(11)53(65(94)78-51)80-63(92)45-27-26-40(9)61-55(45)77-57-50(56(60(91)41(10)62(57)105-61)76-29-23-28-75-44-32-73(13,14)88(102)74(15,16)33-44)64(93)81-54-43(12)104-72(101)59(39(7)8)85(20)49(90)35-83(18)68(97)47-25-22-31-87(47)70(99)52(37(3)4)79-66(54)95/h26-27,36-39,42-44,46-47,51-54,58-59,75-76H,21-25,28-35H2,1-20H3,(H,78,94)(H,79,95)(H,80,92)(H,81,93)/t42-,43-,46+,47+,51-,52-,53+,54+,58+,59+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase |
J Med Chem 22: 1051-5 (1979)
BindingDB Entry DOI: 10.7270/Q2SQ91WG |
More data for this
Ligand-Target Pair | |
DNA-directed RNA polymerase subunit alpha/beta/beta'/omega
(Escherichia coli K-12) | BDBM50000054
(CHEMBL3228735)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(NC5CC(C)(C)[N+]([O-])C(C)(C)C5)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |r,wU:12.13,8.107,51.53,46.48,1.0,wD:45.46,72.79,87.94,82.89,64.66,^1:35,(36.21,-4.82,;37.96,-4.15,;36.92,-3.01,;37.68,-1.67,;39.19,-1.98,;39.37,-3.5,;40.71,-4.27,;40.71,-5.81,;42.04,-3.5,;43.37,-4.27,;45.91,-10.38,;47.24,-11.15,;44.57,-11.13,;44.56,-12.67,;45.89,-13.46,;47.22,-12.69,;45.88,-15,;44.55,-15.75,;44.53,-17.29,;45.86,-18.08,;45.84,-19.62,;47.2,-17.31,;48.52,-18.08,;49.85,-17.33,;51.16,-18.1,;51.14,-19.65,;52.48,-17.34,;53.82,-18.12,;52.49,-15.82,;53.82,-15.05,;55.16,-15.82,;55.15,-17.35,;56.47,-18.11,;57.24,-19.44,;55.7,-19.44,;57.81,-17.36,;59.14,-18.13,;57.81,-15.81,;58.9,-14.72,;59.31,-16.21,;56.48,-15.04,;51.16,-15.05,;51.18,-13.51,;49.86,-12.74,;52.52,-12.74,;52.52,-11.2,;53.86,-10.43,;53.87,-8.91,;55.19,-11.22,;56.53,-10.45,;56.53,-8.91,;57.86,-11.22,;57.85,-12.76,;59.19,-13.53,;56.52,-13.53,;59.2,-10.45,;60.53,-11.24,;59.21,-8.91,;57.87,-8.14,;60.54,-8.16,;60.54,-6.6,;61.9,-5.85,;59.21,-5.83,;57.88,-6.6,;59.23,-4.29,;60.88,-5.16,;60.49,-3.4,;60.01,-1.93,;58.47,-1.93,;57.99,-3.38,;56.65,-4.15,;56.65,-5.69,;55.32,-3.38,;53.98,-4.13,;51.19,-10.43,;49.86,-11.19,;55.32,-1.82,;53.99,-1.05,;56.66,-1.05,;49.86,-15.8,;48.53,-15.03,;47.21,-15.77,;43.24,-10.36,;43.25,-8.82,;41.9,-11.12,;40.57,-10.34,;40.59,-8.8,;39.24,-11.1,;39.22,-12.64,;40.55,-13.42,;37.89,-13.39,;37.9,-10.31,;36.57,-11.08,;37.91,-8.77,;39.26,-8.02,;36.58,-8,;36.6,-6.46,;35.27,-5.67,;37.95,-5.69,;39.26,-6.46,;42.02,-1.96,;43.36,-1.19,;40.69,-1.19,)| Show InChI InChI=1S/C71H102N13O17/c1-33(2)48-66(94)82-27-21-23-43(82)64(92)78(17)31-45(85)80(19)55(35(5)6)68(96)99-39(11)50(62(90)74-48)76-60(88)42-26-25-37(9)58-52(42)73-54-47(53(57(87)38(10)59(54)101-58)72-41-29-70(13,14)84(98)71(15,16)30-41)61(89)77-51-40(12)100-69(97)56(36(7)8)81(20)46(86)32-79(18)65(93)44-24-22-28-83(44)67(95)49(34(3)4)75-63(51)91/h25-26,33-36,39-41,43-44,48-51,55-56,72H,21-24,27-32H2,1-20H3,(H,74,90)(H,75,91)(H,76,88)(H,77,89)/t39-,40-,43+,44+,48-,49-,50+,51+,55+,56+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase |
J Med Chem 22: 1051-5 (1979)
BindingDB Entry DOI: 10.7270/Q2SQ91WG |
More data for this
Ligand-Target Pair | |
DNA-directed RNA polymerase subunit beta'
(Escherichia coli K-12) | BDBM50000055
(CHEMBL3228736)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(NCCNC5CC(C)(C)[N+]([O-])C(C)(C)C5)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |r,wU:12.13,8.110,54.56,49.51,1.0,wD:48.49,75.82,90.97,85.92,67.69,^1:38,(.5,-24.4,;2.24,-23.73,;1.21,-22.59,;1.96,-21.26,;3.48,-21.57,;3.66,-23.08,;4.99,-23.85,;4.99,-25.39,;6.32,-23.08,;7.65,-23.85,;10.2,-29.97,;11.53,-30.74,;8.86,-30.71,;8.84,-32.25,;10.17,-33.05,;11.5,-32.28,;10.17,-34.59,;8.84,-35.33,;8.81,-36.87,;10.14,-37.67,;10.13,-39.2,;11.48,-36.9,;12.8,-37.67,;14.13,-36.91,;15.45,-37.68,;15.42,-39.23,;16.77,-36.92,;18.11,-37.71,;16.78,-35.4,;18.11,-34.63,;19.44,-35.4,;20.77,-34.63,;22.11,-35.4,;22.11,-36.94,;23.44,-37.7,;23.43,-39.24,;24.97,-39.24,;24.2,-40.57,;22.1,-40.01,;22.1,-41.55,;20.77,-39.23,;19.99,-40.56,;19.23,-39.22,;20.77,-37.7,;15.45,-34.63,;15.46,-33.09,;14.14,-32.32,;16.8,-32.32,;16.8,-30.78,;18.15,-30.01,;18.15,-28.49,;19.48,-30.8,;20.81,-30.03,;20.81,-28.5,;22.14,-30.81,;22.14,-32.35,;23.47,-33.12,;20.81,-33.12,;23.49,-30.04,;24.82,-30.82,;23.5,-28.5,;22.16,-27.73,;24.83,-27.74,;24.83,-26.19,;26.18,-25.43,;23.5,-25.42,;22.17,-26.19,;23.51,-23.88,;25.17,-24.74,;24.77,-22.98,;24.29,-21.51,;22.75,-21.51,;22.28,-22.97,;20.93,-23.73,;20.93,-25.28,;19.6,-22.96,;18.26,-23.71,;15.47,-30.01,;14.14,-30.78,;19.6,-21.4,;18.27,-20.63,;20.95,-20.63,;14.14,-35.38,;12.81,-34.61,;11.5,-35.36,;7.53,-29.94,;7.54,-28.4,;6.18,-30.71,;4.85,-29.92,;4.88,-28.38,;3.52,-30.68,;3.5,-32.22,;4.83,-33,;2.17,-32.98,;2.19,-29.9,;.86,-30.66,;2.19,-28.36,;3.55,-27.6,;.86,-27.58,;.89,-26.04,;-.44,-25.25,;2.23,-25.28,;3.55,-26.05,;6.3,-21.54,;7.65,-20.77,;4.97,-20.77,)| Show InChI InChI=1S/C73H107N14O17/c1-35(2)50-68(97)85-29-21-23-45(85)66(95)81(17)33-47(88)83(19)57(37(5)6)70(99)102-41(11)52(64(93)77-50)79-62(91)44-26-25-39(9)60-54(44)76-56-49(55(59(90)40(10)61(56)104-60)75-28-27-74-43-31-72(13,14)87(101)73(15,16)32-43)63(92)80-53-42(12)103-71(100)58(38(7)8)84(20)48(89)34-82(18)67(96)46-24-22-30-86(46)69(98)51(36(3)4)78-65(53)94/h25-26,35-38,41-43,45-46,50-53,57-58,74-75H,21-24,27-34H2,1-20H3,(H,77,93)(H,78,94)(H,79,91)(H,80,92)/t41-,42-,45+,46+,50-,51-,52+,53+,57+,58+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase |
J Med Chem 22: 1051-5 (1979)
BindingDB Entry DOI: 10.7270/Q2SQ91WG |
More data for this
Ligand-Target Pair | |
DNA-directed RNA polymerase subunit beta'
(Escherichia coli K-12) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli DNA-primed RNA polymerase activity using [8-14C]ATP by scintillation counting |
J Med Chem 19: 994-8 (1976)
BindingDB Entry DOI: 10.7270/Q2668FQC |
More data for this
Ligand-Target Pair | |
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