The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
20085328 |
18 |
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.![EBI](/images/logo_chembl.png) |
Duquesne University |
18680275 |
14 |
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.![EBI](/images/logo_chembl.png) |
Wayne State University School of Medicine |
1578484 |
26 |
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.![EBI](/images/logo_chembl.png) |
Harvard Medical School |
2709379 |
2 |
A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant.![EBI](/images/logo_chembl.png) |
Pennsylvania State University |
| 3 |
Synthesis of a pyrimido[4,5-b]azepine analog of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)![EBI](/images/logo_chembl.png) |
TBA |
| 6 |
Synthesis and biological activity of 2-desamino and 4-deoxy analogs of 5,10-dideazatetrahydrofolic acid (DDATHF)![EBI](/images/logo_chembl.png) |
TBA |
| 3 |
Synthesis and biological activity of nor- and homo-5,10-dideazatetrahydrofolic acid![EBI](/images/logo_chembl.png) |
TBA |
19371039 |
14 |
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.![EBI](/images/logo_chembl.png) |
Wayne State University School of Medicine |
9990460 |
9 |
The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents.![EBI](/images/logo_chembl.png) |
Eli Lilly |
3599031 |
12 |
N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase.![EBI](/images/logo_chembl.png) |
TBA |
3184124 |
28 |
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.![EBI](/images/logo_chembl.png) |
Southern Research Institute |
2498518 |
10 |
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.![EBI](/images/logo_chembl.png) |
University of South Alabama |
2296020 |
18 |
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.![EBI](/images/logo_chembl.png) |
Sri International |
1433179 |
13 |
5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities.![EBI](/images/logo_chembl.png) |
Duquesne University |
1375963 |
4 |
Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine.![EBI](/images/logo_chembl.png) |
Medical University of South Carolina |