The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
24035338 |
82 |
Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.![EBI](/images/logo_chembl.png) |
Toray Industries |
21354674 |
14 |
The many faces of the adamantyl group in drug design.![EBI](/images/logo_chembl.png) |
University of Sydney |
19645482 |
245 |
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.![EBI](/images/logo_chembl.png) |
Merck Research Laboratories |
17616115 |
61 |
Orally bioavailable potent soluble epoxide hydrolase inhibitors.![EBI](/images/logo_chembl.png) |
University of California Davis |
21211973 |
35 |
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.![EBI](/images/logo_chembl.png) |
Ar£Te Therapeutics |
20812725 |
103 |
1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.![EBI](/images/logo_chembl.png) |
Department of Entomology and University of California Davis Cancer Center |
17046265 |
66 |
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase.![EBI](/images/logo_chembl.png) |
Department of Entomology and University of California Davis Cancer Center |
16908134 |
98 |
Peptidyl-urea based inhibitors of soluble epoxide hydrolases.![EBI](/images/logo_chembl.png) |
University of California |
15887969 |
64 |
Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility.![EBI](/images/logo_chembl.png) |
Department of Entomology and University of California Davis Cancer Center |
15056008 |
72 |
Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.![EBI](/images/logo_chembl.png) |
University of California Davis |
12620084 |
17 |
QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds.![EBI](/images/logo_chembl.png) |
The Pennsylvania State University |
31436984 |
54 |
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.![EBI](/images/logo_chembl.png) |
Goethe-University Frankfurt |
31488357 |
19 |
Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.![EBI](/images/logo_chembl.png) |
Universitat De Barcelona |
8423594 |
39 |
Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.![EBI](/images/logo_chembl.png) |
Scripps Research Institute |
29366648 |
98 |
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.![EBI](/images/logo_chembl.png) |
University of California Davis |
29803731 |
68 |
Adamantyl thioureas as soluble epoxide hydrolase inhibitors.![EBI](/images/logo_chembl.png) |
University of California Davis |