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PubMed code 8423594

Compile data set for download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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 18n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046314
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H23NO4/c25-22(23(26)24(27)29-17-20-9-5-2-6-10-20)15-18-11-13-21(14-12-18)28-16-19-7-3-1-4-8-19/h1-14,22H,15-17,25H2/t22-/m0/s1
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 46n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Mus musculus (Mouse))		BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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 100n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition constant was determined against epoxide hydrolase

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Mus musculus (Mouse))		BDBM50046314
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H23NO4/c25-22(23(26)24(27)29-17-20-9-5-2-6-10-20)15-18-11-13-21(14-12-18)28-16-19-7-3-1-4-8-19/h1-14,22H,15-17,25H2/t22-/m0/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition constant was determined against epoxide hydrolase

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046327
PNG
(3-Amino-1,4-diphenyl-butan-2-one | CHEMBL70658)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C16H17NO/c17-15(11-13-7-3-1-4-8-13)16(18)12-14-9-5-2-6-10-14/h1-10,15H,11-12,17H2/t15-/m0/s1
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 1.40E+4n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046331
PNG
(((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-...)
Show SMILES N[C@@H](Cc1ccccc1)[C@H](O)C(=O)NCC(O)=O
Show InChI InChI=1S/C12H16N2O4/c13-9(6-8-4-2-1-3-5-8)11(17)12(18)14-7-10(15)16/h1-5,9,11,17H,6-7,13H2,(H,14,18)(H,15,16)/t9-,11-/m0/s1
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 1.50E+4n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50279808
PNG
((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid me...)
Show SMILES COC(=O)[C@@H](O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C11H15NO3/c1-15-11(14)10(13)9(12)7-8-5-3-2-4-6-8/h2-6,9-10,13H,7,12H2,1H3/t9-,10-/m0/s1
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 5.00E+4n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046326
PNG
(2-(3-Amino-2-oxo-4-phenyl-butyrylamino)-4-methyl-p...)
Show SMILES CC(C)C[C@H](NC(=O)C(=O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H22N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against aminopeptidase M

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046329
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Show SMILES COC(=O)C(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H19NO4/c1-22-18(21)17(20)16(19)11-13-7-9-15(10-8-13)23-12-14-5-3-2-4-6-14/h2-10,16H,11-12,19H2,1H3/t16-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046321
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-hydroxy-butyric a...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)[C@H](O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H25NO4/c25-22(23(26)24(27)29-17-20-9-5-2-6-10-20)15-18-11-13-21(14-12-18)28-16-19-7-3-1-4-8-19/h1-14,22-23,26H,15-17,25H2/t22-,23-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046319
PNG
(3-[2-Amino-3-(4-benzyloxy-phenyl)-propionyl]-benzo...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C23H21NO4/c24-21(22(25)18-7-4-8-19(14-18)23(26)27)13-16-9-11-20(12-10-16)28-15-17-5-2-1-3-6-17/h1-12,14,21H,13,15,24H2,(H,26,27)/t21-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046315
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-1-(4-trifluoromethy...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H20F3NO2/c24-23(25,26)19-10-8-18(9-11-19)22(28)21(27)14-16-6-12-20(13-7-16)29-15-17-4-2-1-3-5-17/h1-13,21H,14-15,27H2/t21-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046325
PNG
((S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyryla...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046340
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-hydroxy-butyric a...)
Show SMILES COC(=O)[C@@H](O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO4/c1-22-18(21)17(20)16(19)11-13-7-9-15(10-8-13)23-12-14-5-3-2-4-6-14/h2-10,16-17,20H,11-12,19H2,1H3/t16-,17-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046335
PNG
(6-Amino-5-oxo-7-phenyl-heptanoic acid | CHEMBL3077...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)CCCC(O)=O
Show InChI InChI=1S/C13H17NO3/c14-11(9-10-5-2-1-3-6-10)12(15)7-4-8-13(16)17/h1-3,5-6,11H,4,7-9,14H2,(H,16,17)/t11-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046320
PNG
(3-Amino-2-hydroxy-4-phenyl-butyric acid benzyl est...)
Show SMILES N[C@@H](Cc1ccccc1)[C@H](O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C17H19NO3/c18-15(11-13-7-3-1-4-8-13)16(19)17(20)21-12-14-9-5-2-6-10-14/h1-10,15-16,19H,11-12,18H2/t15-,16-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50046329
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Show SMILES COC(=O)C(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H19NO4/c1-22-18(21)17(20)16(19)11-13-7-9-15(10-8-13)23-12-14-5-3-2-4-6-14/h2-10,16H,11-12,19H2,1H3/t16-/m0/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against cytosolic leucine aminopeptidase

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against cytosolic leucine aminopeptidase

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046337
PNG
(3-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino...)
Show SMILES N[C@@H](Cc1ccccc1)[C@H](O)C(=O)NCCC(O)=O
Show InChI InChI=1S/C13H18N2O4/c14-10(8-9-4-2-1-3-5-9)12(18)13(19)15-7-6-11(16)17/h1-5,10,12,18H,6-8,14H2,(H,15,19)(H,16,17)/t10-,12-/m0/s1
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n/an/a 8.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM50046329
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Show SMILES COC(=O)C(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H19NO4/c1-22-18(21)17(20)16(19)11-13-7-9-15(10-8-13)23-12-14-5-3-2-4-6-14/h2-10,16H,11-12,19H2,1H3/t16-/m0/s1
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n/an/a 8.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against aminopeptidase M

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046330
PNG
(3-Amino-2-oxo-4-phenyl-butyric acid methyl ester |...)
Show SMILES COC(=O)C(=O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C11H13NO3/c1-15-11(14)10(13)9(12)7-8-5-3-2-4-6-8/h2-6,9H,7,12H2,1H3/t9-/m0/s1
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n/an/a 8.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50046321
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-hydroxy-butyric a...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)[C@H](O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H25NO4/c25-22(23(26)24(27)29-17-20-9-5-2-6-10-20)15-18-11-13-21(14-12-18)28-16-19-7-3-1-4-8-19/h1-14,22-23,26H,15-17,25H2/t22-,23-/m0/s1
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n/an/a 8.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against cytosolic leucine aminopeptidase

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046318
PNG
((2-Amino-3-phenyl-ethylphosphonylamino)-acetic aci...)
Show SMILES NC(Cc1ccccc1)P(O)(=O)NCC(O)=O
Show InChI InChI=1S/C10H15N2O4P/c11-9(6-8-4-2-1-3-5-8)17(15,16)12-7-10(13)14/h1-5,9H,6-7,11H2,(H,13,14)(H2,12,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046333
PNG
(3-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyrylamino...)
Show SMILES N[C@H](Cc1ccccc1)[C@H](O)C(=O)NCCC(O)=O
Show InChI InChI=1S/C13H18N2O4/c14-10(8-9-4-2-1-3-5-9)12(18)13(19)15-7-6-11(16)17/h1-5,10,12,18H,6-8,14H2,(H,15,19)(H,16,17)/t10-,12+/m1/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM50046321
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-hydroxy-butyric a...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)[C@H](O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H25NO4/c25-22(23(26)24(27)29-17-20-9-5-2-6-10-20)15-18-11-13-21(14-12-18)28-16-19-7-3-1-4-8-19/h1-14,22-23,26H,15-17,25H2/t22-,23-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against aminopeptidase M

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046334
PNG
(2-(3-Amino-2-hydroxy-4-phenyl-thiobutyrylamino)-4-...)
Show SMILES CC(C)C[C@H](NC(=S)[C@H](O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3S/c1-10(2)8-13(16(20)21)18-15(22)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,22)(H,20,21)/t12-,13-,14+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50046314
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H23NO4/c25-22(23(26)24(27)29-17-20-9-5-2-6-10-20)15-18-11-13-21(14-12-18)28-16-19-7-3-1-4-8-19/h1-14,22H,15-17,25H2/t22-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against cytosolic leucine aminopeptidase

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50022747
PNG
(2-(3-Amino-2-hydroxy-4-phenyl-thiobutyrylamino)-4-...)
Show SMILES CC(C)C[C@H](NC(=S)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3S/c1-10(2)8-13(16(20)21)18-15(22)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,22)(H,20,21)/t12-,13+,14+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046328
PNG
(3-Amino-N-benzyl-2-hydroxy-4-phenyl-butyramide | C...)
Show SMILES N[C@@H](Cc1ccccc1)[C@H](O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H20N2O2/c18-15(11-13-7-3-1-4-8-13)16(20)17(21)19-12-14-9-5-2-6-10-14/h1-10,15-16,20H,11-12,18H2,(H,19,21)/t15-,16-/m0/s1
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM50046314
PNG
(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H23NO4/c25-22(23(26)24(27)29-17-20-9-5-2-6-10-20)15-18-11-13-21(14-12-18)28-16-19-7-3-1-4-8-19/h1-14,22H,15-17,25H2/t22-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against aminopeptidase M

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046324
PNG
(2-(3-Amino-2-hydroxy-4-phenyl-thiobutyrylamino)-4-...)
Show SMILES CC(C)C[C@H](NC(=S)[C@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3S/c1-10(2)8-13(16(20)21)18-15(22)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,22)(H,20,21)/t12-,13+,14-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046313
PNG
(3-Amino-1,4-diphenyl-butan-2-ol | CHEMBL69297)
Show SMILES N[C@@H](Cc1ccccc1)[C@H](O)Cc1ccccc1
Show InChI InChI=1S/C16H19NO/c17-15(11-13-7-3-1-4-8-13)16(18)12-14-9-5-2-6-10-14/h1-10,15-16,18H,11-12,17H2/t15-,16+/m0/s1
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n/an/a 1.40E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046323
PNG
(3-Amino-2-mercapto-4-phenyl-butyric acid methyl es...)
Show SMILES COC(=O)C(S)C(N)Cc1ccccc1
Show InChI InChI=1S/C11H15NO2S/c1-14-11(13)10(15)9(12)7-8-5-3-2-4-6-8/h2-6,9-10,15H,7,12H2,1H3
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n/an/a 2.50E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046317
PNG
(2-(3-Amino-2-mercapto-4-phenyl-butyrylamino)-4-met...)
Show SMILES CC(C)C[C@H](NC(=O)C(S)C(N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3S/c1-10(2)8-13(16(20)21)18-15(19)14(22)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,22H,8-9,17H2,1-2H3,(H,18,19)(H,20,21)/t12?,13-,14?/m0/s1
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046322
PNG
((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid me...)
Show SMILES COC(=O)[C@H](O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C11H15NO3/c1-15-11(14)10(13)9(12)7-8-5-3-2-4-6-8/h2-6,9-10,13H,7,12H2,1H3/t9-,10+/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046339
PNG
((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid | ...)
Show SMILES N[C@@H](Cc1ccccc1)[C@H](O)C(O)=O
Show InChI InChI=1S/C10H13NO3/c11-8(9(12)10(13)14)6-7-4-2-1-3-5-7/h1-5,8-9,12H,6,11H2,(H,13,14)/t8-,9-/m0/s1
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046338
PNG
(3,3-Difluoro-4-(5-methyl-1H-imidazol-4-yl)-4-oxo-b...)
Show SMILES CCOC(=O)CC(F)(F)C(=O)c1[nH]cnc1C
Show InChI InChI=1S/C10H12F2N2O3/c1-3-17-7(15)4-10(11,12)9(16)8-6(2)13-5-14-8/h5H,3-4H2,1-2H3,(H,13,14)
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50046332
PNG
((E)-3,3-Difluoro-4-oxo-6-phenyl-hex-5-enoic acid e...)
Show SMILES CCOC(=O)CC(F)(F)C(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C14H14F2O3/c1-2-19-13(18)10-14(15,16)12(17)9-8-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3/b9-8+
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n/an/a>5.00E+6n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytes

J Med Chem 36: 211-20 (1993)


BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%