The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
23562062 |
4 |
Arylsulfonamide pyrimidines as VLA-4 antagonists. |
Elan Pharmaceuticals |
15214773 |
76 |
Fragment-based drug discovery. |
Sunesis Pharmaceuticals |
12139455 |
78 |
Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents. |
Genentech |
21109434 |
40 |
Structure-activity relationship (SAR) of thea-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. |
Sunesis Pharmaceuticals |
15686933 |
12 |
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold. |
Cerep |
15481974 |
43 |
Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives. |
Boehringer Ingelheim Pharmaceuticals |
11728185 |
55 |
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide. |
Abbott Laboratories |
11312920 |
23 |
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. |
Abbott Laboratories |
31999923 |
16 |
Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations. |
Pliant Therapeutics |
7707308 |
3 |
Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. |
R. W. Johnson Pharmaceutical Research Institute |