The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
32324396 |
17 |
p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
China Pharmaceutical University |
32832028 |
47 |
Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity. |
Genentech |
32832022 |
33 |
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors. |
Merck |
32551006 |
134 |
Discovery of an Atropisomeric PI3K? Selective Inhibitor through Optimization of the Hinge Binding Motif. |
Gilead Sciences |
32035698 |
40 |
Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ. |
Bristol-Myers Squibb Research and Development |
27366941 |
44 |
Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles. |
Vertex Pharmaceuticals |
31749906 |
52 |
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy. |
Merck |
31246024 |
106 |
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy. |
Bristol-Myers Squibb Research & Development |
32297743 |
59 |
Discovery of (2 |
Astrazeneca |
31851518 |
61 |
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- |
Astrazeneca |
30500190 |
36 |
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model. |
TBA |
30929436 |
88 |
Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease. |
TBA |
32184970 |
55 |
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. |
Gilead Sciences |
30638874 |
64 |
Discovery of new indole-based acylsulfonamide Na |
Bristol-Myers Squibb Research and Development |