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PubMed code 31246024

Compile data set for download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528302
PNG
(CHEMBL4551932)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCCOc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-15-10-18(29-9-8-28-14-6-4-3-5-7-14)16-12-20(30-19(16)11-15)17-13-25-21(23-17)31-22(24-25)27-2/h3-7,10-13H,8-9H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528303
PNG
(CHEMBL4462511)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(Sc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N3O4S2/c1-31-18-12-23(33-16-17-7-6-10-20(11-17)35-19-8-4-3-5-9-19)21-14-25(34-24(21)13-18)22-15-30-26(28-22)36-27(29-30)32-2/h3-15H,16H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528281
PNG
(CHEMBL4457190)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C22H16N4O4S/c1-27-15-7-18(29-12-14-5-3-4-13(6-14)10-23)16-9-20(30-19(16)8-15)17-11-26-21(24-17)31-22(25-26)28-2/h3-9,11H,12H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364615
PNG
(US9862730, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cc(OC)cc2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-8-4-11(20-2)9-6-13(22-12(9)5-8)10-7-18-14(16-10)23-15(17-18)21-3/h4-7H,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528290
PNG
(CHEMBL4457819)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O4S/c1-26-15-10-18(28-9-8-14-6-4-3-5-7-14)16-12-20(29-19(16)11-15)17-13-25-21(23-17)30-22(24-25)27-2/h3-7,10-13H,8-9H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364613
PNG
(US9862730, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)cc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-9-4-3-8-5-12(20-11(8)6-9)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528296
PNG
(CHEMBL4461217)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(Oc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N3O5S/c1-31-20-12-23(33-16-17-7-6-10-19(11-17)34-18-8-4-3-5-9-18)21-14-25(35-24(21)13-20)22-15-30-26(28-22)36-27(29-30)32-2/h3-15H,16H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528287
PNG
(CHEMBL4447049)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(OCc4ccccc4)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-8-10-20(11-9-19)34-16-18-6-4-3-5-7-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528295
PNG
(CHEMBL4539616)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-14-6-4-13(5-7-14)12-29-18-8-15(27-2)9-19-16(18)10-20(30-19)17-11-25-21(23-17)31-22(24-25)28-3/h4-11H,12H2,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528291
PNG
(CHEMBL4452111)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3C)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O4S/c1-13-6-4-5-7-14(13)12-28-18-8-15(26-2)9-19-16(18)10-20(29-19)17-11-25-21(23-17)30-22(24-25)27-3/h4-11H,12H2,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528282
PNG
(CHEMBL4580391)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCCOCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H21N3O5S/c1-27-16-10-19(30-9-8-29-14-15-6-4-3-5-7-15)17-12-21(31-20(17)11-16)18-13-26-22(24-18)32-23(25-26)28-2/h3-7,10-13H,8-9,14H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528292
PNG
(CHEMBL4537548)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3Cl)cc(OC)cc2o1
Show InChI InChI=1S/C21H16ClN3O4S/c1-26-13-7-17(28-11-12-5-3-4-6-15(12)22)14-9-19(29-18(14)8-13)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528297
PNG
(CHEMBL4441723)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(CCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O4S/c1-33-22-14-25(35-18-21-10-6-9-20(13-21)12-11-19-7-4-3-5-8-19)23-16-27(36-26(23)15-22)24-17-32-28(30-24)37-29(31-32)34-2/h3-10,13-17H,11-12,18H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364569
PNG
(2-Methoxy-6-(7-methoxybenzofuran-2-yl)imidazo[2,1-...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cccc(OC)c2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-10-5-3-4-8-6-11(20-12(8)10)9-7-17-13(15-9)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528280
PNG
(CHEMBL4483493)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C21H17N3O5S/c1-26-14-7-17(28-11-12-4-3-5-13(25)6-12)15-9-19(29-18(15)8-14)16-10-24-20(22-16)30-21(23-24)27-2/h3-10,25H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528293
PNG
(CHEMBL4523001)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C22H16F3N3O4S/c1-29-14-7-17(31-11-12-4-3-5-13(6-12)22(23,24)25)15-9-19(32-18(15)8-14)16-10-28-20(26-16)33-21(27-28)30-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528298
PNG
(CHEMBL4465125)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(COc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-8-6-7-18(11-19)16-34-20-9-4-3-5-10-20)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528279
PNG
(CHEMBL4528562)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3OCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-20-12-24(35-17-19-10-6-7-11-23(19)34-16-18-8-4-3-5-9-18)21-14-26(36-25(21)13-20)22-15-31-27(29-22)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528284
PNG
(CHEMBL4474285)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C21H16ClN3O4S/c1-26-14-7-17(28-11-12-4-3-5-13(22)6-12)15-9-19(29-18(15)8-14)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528305
PNG
(CHEMBL4476101)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C22H16F3N3O4S/c1-29-13-7-17(31-11-12-5-3-4-6-15(12)22(23,24)25)14-9-19(32-18(14)8-13)16-10-28-20(26-16)33-21(27-28)30-2/h3-10H,11H2,1-2H3
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n/an/a 3.40n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199438
PNG
(CHEMBL3931873)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3O2S/c1-17-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)18-11/h2-7H,1H3
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364744
PNG
(6-(4-(Benzyloxy)-6-methoxybenzofuran-2-yl)-2-metho...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C21H17N3O4S/c1-25-14-8-17(27-12-13-6-4-3-5-7-13)15-10-19(28-18(15)9-14)16-11-24-20(22-16)29-21(23-24)26-2/h3-11H,12H2,1-2H3
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n/an/a 4.20n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528294
PNG
(CHEMBL4452516)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(cc3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C22H16F3N3O4S/c1-29-14-7-17(31-11-12-3-5-13(6-4-12)22(23,24)25)15-9-19(32-18(15)8-14)16-10-28-20(26-16)33-21(27-28)30-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364571
PNG
(6-(4-Methoxybenzofuran-2-yl)-2-(methylthio)imidazo...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cccc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-10-4-3-5-11-8(10)6-12(20-11)9-7-17-13(15-9)21-14(16-17)19-2/h3-7H,1-2H3
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n/an/a 7.60n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528300
PNG
(CHEMBL4459685)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-14-6-4-5-13(7-14)12-29-18-8-15(27-2)9-19-16(18)10-20(30-19)17-11-25-21(23-17)31-22(24-25)28-3/h4-11H,12H2,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528283
PNG
(CHEMBL4454407)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C21H16ClN3O4S/c1-26-14-7-17(28-11-12-3-5-13(22)6-4-12)15-9-19(29-18(15)8-14)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364565
PNG
(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Show SMILES CSc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3OS2/c1-18-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)17-11/h2-7H,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364644
PNG
(US9862730, Example 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)ccc(OC)c2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-10-4-5-11(20-2)13-8(10)6-12(22-13)9-7-18-14(16-9)23-15(17-18)21-3/h4-7H,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528301
PNG
(CHEMBL4445561)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-14-8-18(29-12-13-6-4-5-7-17(13)27-2)15-10-20(30-19(15)9-14)16-11-25-21(23-16)31-22(24-25)28-3/h4-11H,12H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364751
PNG
(6-(4-(Benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3)cccc2o1
Show InChI InChI=1S/C20H15N3O3S/c1-24-20-22-23-11-15(21-19(23)27-20)18-10-14-16(8-5-9-17(14)26-18)25-12-13-6-3-2-4-7-13/h2-11H,12H2,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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n/an/a 25n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364645
PNG
(US9862730, Example 104)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OCc3ccccc3)cc2o1
Show InChI InChI=1S/C20H15N3O3S/c1-24-20-22-23-11-16(21-19(23)27-20)18-9-14-7-8-15(10-17(14)26-18)25-12-13-5-3-2-4-6-13/h2-11H,12H2,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528299
PNG
(CHEMBL4529377)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(CO)c3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-27-15-7-18(29-12-14-5-3-4-13(6-14)11-26)16-9-20(30-19(16)8-15)17-10-25-21(23-17)31-22(24-25)28-2/h3-10,26H,11-12H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364589
PNG
(US9862730, Example 41)
Show SMILES Cc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3OS/c1-8-15-16-7-10(14-13(16)18-8)12-6-9-4-2-3-5-11(9)17-12/h2-7H,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364594
PNG
(US9862730, Example 47)
Show SMILES CCc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C14H11N3OS/c1-2-13-16-17-8-10(15-14(17)19-13)12-7-9-5-3-4-6-11(9)18-12/h3-8H,2H2,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528304
PNG
(CHEMBL3732510)
Show SMILES CCOc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C14H11N3O2S/c1-2-18-14-16-17-8-10(15-13(17)20-14)12-7-9-5-3-4-6-11(9)19-12/h3-8H,2H2,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364615
PNG
(US9862730, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cc(OC)cc2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-8-4-11(20-2)9-6-13(22-12(9)5-8)10-7-18-14(16-10)23-15(17-18)21-3/h4-7H,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364611
PNG
(US9862730, Example 69)
Show SMILES CNc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N4OS/c1-14-12-16-17-7-9(15-13(17)19-12)11-6-8-4-2-3-5-10(8)18-11/h2-7H,1H3,(H,14,16)
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364613
PNG
(US9862730, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)cc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-9-4-3-8-5-12(20-11(8)6-9)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364634
PNG
(US9862730, Example 93)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC)ccc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-9-3-4-11-8(5-9)6-12(20-11)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199438
PNG
(CHEMBL3931873)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3O2S/c1-17-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)18-11/h2-7H,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364569
PNG
(2-Methoxy-6-(7-methoxybenzofuran-2-yl)imidazo[2,1-...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cccc(OC)c2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-10-5-3-4-8-6-11(20-12(8)10)9-7-17-13(15-9)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364565
PNG
(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Show SMILES CSc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3OS2/c1-18-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)17-11/h2-7H,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364571
PNG
(6-(4-Methoxybenzofuran-2-yl)-2-(methylthio)imidazo...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cccc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-10-4-3-5-11-8(10)6-12(20-11)9-7-17-13(15-9)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528296
PNG
(CHEMBL4461217)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(Oc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N3O5S/c1-31-20-12-23(33-16-17-7-6-10-19(11-17)34-18-8-4-3-5-9-18)21-14-25(35-24(21)13-20)22-15-30-26(28-22)36-27(29-30)32-2/h3-15H,16H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528303
PNG
(CHEMBL4462511)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(Sc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N3O4S2/c1-31-18-12-23(33-16-17-7-6-10-20(11-17)35-19-8-4-3-5-9-19)21-14-25(34-24(21)13-18)22-15-30-26(28-22)36-27(29-30)32-2/h3-15H,16H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528293
PNG
(CHEMBL4523001)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C22H16F3N3O4S/c1-29-14-7-17(31-11-12-4-3-5-13(6-12)22(23,24)25)15-9-19(32-18(15)8-14)16-10-28-20(26-16)33-21(27-28)30-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364613
PNG
(US9862730, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)cc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-9-4-3-8-5-12(20-11(8)6-9)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528302
PNG
(CHEMBL4551932)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCCOc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-15-10-18(29-9-8-28-14-6-4-3-5-7-14)16-12-20(30-19(16)11-15)17-13-25-21(23-17)31-22(24-25)27-2/h3-7,10-13H,8-9H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528282
PNG
(CHEMBL4580391)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCCOCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H21N3O5S/c1-27-16-10-19(30-9-8-29-14-15-6-4-3-5-7-15)17-12-21(31-20(17)11-16)18-13-26-22(24-18)32-23(25-26)28-2/h3-7,10-13H,8-9,14H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364615
PNG
(US9862730, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cc(OC)cc2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-8-4-11(20-2)9-6-13(22-12(9)5-8)10-7-18-14(16-10)23-15(17-18)21-3/h4-7H,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364605
PNG
(US9862730, Example 63)
Show SMILES C1CC1c1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C15H11N3OS/c1-2-4-12-10(3-1)7-13(19-12)11-8-18-15(16-11)20-14(17-18)9-5-6-9/h1-4,7-9H,5-6H2
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528287
PNG
(CHEMBL4447049)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(OCc4ccccc4)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-8-10-20(11-9-19)34-16-18-6-4-3-5-7-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528298
PNG
(CHEMBL4465125)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(COc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-8-6-7-18(11-19)16-34-20-9-4-3-5-10-20)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528284
PNG
(CHEMBL4474285)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C21H16ClN3O4S/c1-26-14-7-17(28-11-12-4-3-5-13(22)6-12)15-9-19(29-18(15)8-14)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528285
PNG
(CHEMBL4572935)
Show SMILES CC(C)Oc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C15H13N3O2S/c1-9(2)19-15-17-18-8-11(16-14(18)21-15)13-7-10-5-3-4-6-12(10)20-13/h3-9H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528290
PNG
(CHEMBL4457819)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O4S/c1-26-15-10-18(28-9-8-14-6-4-3-5-7-14)16-12-20(29-19(16)11-15)17-13-25-21(23-17)30-22(24-25)27-2/h3-7,10-13H,8-9H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528281
PNG
(CHEMBL4457190)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C22H16N4O4S/c1-27-15-7-18(29-12-14-5-3-4-13(6-14)10-23)16-9-20(30-19(16)8-15)17-11-26-21(24-17)31-22(25-26)28-2/h3-9,11H,12H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528286
PNG
(CHEMBL4471641)
Show SMILES CS(=O)(=O)c1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3O3S2/c1-21(17,18)13-15-16-7-9(14-12(16)20-13)11-6-8-4-2-3-5-10(8)19-11/h2-7H,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528283
PNG
(CHEMBL4454407)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C21H16ClN3O4S/c1-26-14-7-17(28-11-12-3-5-13(22)6-4-12)15-9-19(29-18(15)8-14)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528305
PNG
(CHEMBL4476101)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C22H16F3N3O4S/c1-29-13-7-17(31-11-12-5-3-4-6-15(12)22(23,24)25)14-9-19(32-18(14)8-13)16-10-28-20(26-16)33-21(27-28)30-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528300
PNG
(CHEMBL4459685)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-14-6-4-5-13(7-14)12-29-18-8-15(27-2)9-19-16(18)10-20(30-19)17-11-25-21(23-17)31-22(24-25)28-3/h4-11H,12H2,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364744
PNG
(6-(4-(Benzyloxy)-6-methoxybenzofuran-2-yl)-2-metho...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C21H17N3O4S/c1-25-14-8-17(27-12-13-6-4-3-5-7-13)15-10-19(28-18(15)9-14)16-11-24-20(22-16)29-21(23-24)26-2/h3-11H,12H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528301
PNG
(CHEMBL4445561)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-14-8-18(29-12-13-6-4-5-7-17(13)27-2)15-10-20(30-19(15)9-14)16-11-25-21(23-16)31-22(24-25)28-3/h4-11H,12H2,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528299
PNG
(CHEMBL4529377)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(CO)c3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-27-15-7-18(29-12-14-5-3-4-13(6-14)11-26)16-9-20(30-19(16)8-15)17-10-25-21(23-17)31-22(24-25)28-2/h3-10,26H,11-12H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528297
PNG
(CHEMBL4441723)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(CCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O4S/c1-33-22-14-25(35-18-21-10-6-9-20(13-21)12-11-19-7-4-3-5-8-19)23-16-27(36-26(23)15-22)24-17-32-28(30-24)37-29(31-32)34-2/h3-10,13-17H,11-12,18H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364571
PNG
(6-(4-Methoxybenzofuran-2-yl)-2-(methylthio)imidazo...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cccc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-10-4-3-5-11-8(10)6-12(20-11)9-7-17-13(15-9)21-14(16-17)19-2/h3-7H,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364744
PNG
(6-(4-(Benzyloxy)-6-methoxybenzofuran-2-yl)-2-metho...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C21H17N3O4S/c1-25-14-8-17(27-12-13-6-4-3-5-7-13)15-10-19(28-18(15)9-14)16-11-24-20(22-16)29-21(23-24)26-2/h3-11H,12H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364570
PNG
(6-(6,7-Dimethoxybenzofuran-2-yl)-2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)c(OC)c2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-10-5-4-8-6-11(22-12(8)13(10)20-2)9-7-18-14(16-9)23-15(17-18)21-3/h4-7H,1-3H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364645
PNG
(US9862730, Example 104)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OCc3ccccc3)cc2o1
Show InChI InChI=1S/C20H15N3O3S/c1-24-20-22-23-11-16(21-19(23)27-20)18-9-14-7-8-15(10-17(14)26-18)25-12-13-5-3-2-4-6-13/h2-11H,12H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528294
PNG
(CHEMBL4452516)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(cc3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C22H16F3N3O4S/c1-29-14-7-17(31-11-12-3-5-13(6-4-12)22(23,24)25)15-9-19(32-18(15)8-14)16-10-28-20(26-16)33-21(27-28)30-2/h3-10H,11H2,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528289
PNG
(CHEMBL4435447)
Show SMILES S(c1nn2cc(nc2s1)-c1cc2ccccc2o1)c1ccccc1
Show InChI InChI=1S/C18H11N3OS2/c1-2-7-13(8-3-1)23-18-20-21-11-14(19-17(21)24-18)16-10-12-6-4-5-9-15(12)22-16/h1-11H
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n/an/a 1.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364644
PNG
(US9862730, Example 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)ccc(OC)c2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-10-4-5-11(20-2)13-8(10)6-12(22-13)9-7-18-14(16-9)23-15(17-18)21-3/h4-7H,1-3H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528304
PNG
(CHEMBL3732510)
Show SMILES CCOc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C14H11N3O2S/c1-2-18-14-16-17-8-10(15-13(17)20-14)12-7-9-5-3-4-6-11(9)19-12/h3-8H,2H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364594
PNG
(US9862730, Example 47)
Show SMILES CCc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C14H11N3OS/c1-2-13-16-17-8-10(15-14(17)19-13)12-7-9-5-3-4-6-11(9)18-12/h3-8H,2H2,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528279
PNG
(CHEMBL4528562)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3OCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-20-12-24(35-17-19-10-6-7-11-23(19)34-16-18-8-4-3-5-9-18)21-14-26(36-25(21)13-20)22-15-31-27(29-22)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528280
PNG
(CHEMBL4483493)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(O)c3)cc(OC)cc2o1
Show InChI InChI=1S/C21H17N3O5S/c1-26-14-7-17(28-11-12-4-3-5-13(25)6-12)15-9-19(29-18(15)8-14)16-10-24-20(22-16)30-21(23-24)27-2/h3-10,25H,11H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528288
PNG
(CHEMBL4444227)
Show SMILES CCSc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C14H11N3OS2/c1-2-19-14-16-17-8-10(15-13(17)20-14)12-7-9-5-3-4-6-11(9)18-12/h3-8H,2H2,1H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528295
PNG
(CHEMBL4539616)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O5S/c1-26-14-6-4-13(5-7-14)12-29-18-8-15(27-2)9-19-16(18)10-20(30-19)17-11-25-21(23-17)31-22(24-25)28-3/h4-11H,12H2,1-3H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528292
PNG
(CHEMBL4537548)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3Cl)cc(OC)cc2o1
Show InChI InChI=1S/C21H16ClN3O4S/c1-26-13-7-17(28-11-12-5-3-4-6-15(12)22)14-9-19(29-18(14)8-13)16-10-25-20(23-16)30-21(24-25)27-2/h3-10H,11H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364751
PNG
(6-(4-(Benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3)cccc2o1
Show InChI InChI=1S/C20H15N3O3S/c1-24-20-22-23-11-15(21-19(23)27-20)18-10-14-16(8-5-9-17(14)26-18)25-12-13-6-3-2-4-7-13/h2-11H,12H2,1H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364569
PNG
(2-Methoxy-6-(7-methoxybenzofuran-2-yl)imidazo[2,1-...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cccc(OC)c2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-10-5-3-4-8-6-11(20-12(8)10)9-7-17-13(15-9)21-14(16-17)19-2/h3-7H,1-2H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528291
PNG
(CHEMBL4452111)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3C)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N3O4S/c1-13-6-4-5-7-14(13)12-28-18-8-15(26-2)9-19-16(18)10-20(29-19)17-11-25-21(23-17)30-22(24-25)27-3/h4-11H,12H2,1-3H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364751
PNG
(6-(4-(Benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3)cccc2o1
Show InChI InChI=1S/C20H15N3O3S/c1-24-20-22-23-11-15(21-19(23)27-20)18-10-14-16(8-5-9-17(14)26-18)25-12-13-6-3-2-4-7-13/h2-11H,12H2,1H3
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n/an/a 4.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364644
PNG
(US9862730, Example 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)ccc(OC)c2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-10-4-5-11(20-2)13-8(10)6-12(22-13)9-7-18-14(16-9)23-15(17-18)21-3/h4-7H,1-3H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199438
PNG
(CHEMBL3931873)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3O2S/c1-17-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)18-11/h2-7H,1H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 in human platelet rich plasma assessed as inhibition of U46619-induced platelet aggregation preincubated for 5 mins follo...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 in human platelet rich plasma assessed as inhibition of SFFLRR-induced platelet aggregation preincubated for 5 mins follo...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364589
PNG
(US9862730, Example 41)
Show SMILES Cc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3OS/c1-8-15-16-7-10(14-13(16)18-8)12-6-9-4-2-3-5-11(9)17-12/h2-7H,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528285
PNG
(CHEMBL4572935)
Show SMILES CC(C)Oc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C15H13N3O2S/c1-9(2)19-15-17-18-8-11(16-14(18)21-15)13-7-10-5-3-4-6-12(10)20-13/h3-9H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364645
PNG
(US9862730, Example 104)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OCc3ccccc3)cc2o1
Show InChI InChI=1S/C20H15N3O3S/c1-24-20-22-23-11-16(21-19(23)27-20)18-9-14-7-8-15(10-17(14)26-18)25-12-13-5-3-2-4-6-13/h2-11H,12H2,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364570
PNG
(6-(6,7-Dimethoxybenzofuran-2-yl)-2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)c(OC)c2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-10-5-4-8-6-11(22-12(8)13(10)20-2)9-7-18-14(16-9)23-15(17-18)21-3/h4-7H,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364605
PNG
(US9862730, Example 63)
Show SMILES C1CC1c1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C15H11N3OS/c1-2-4-12-10(3-1)7-13(19-12)11-8-18-15(16-11)20-14(17-18)9-5-6-9/h1-4,7-9H,5-6H2
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364611
PNG
(US9862730, Example 69)
Show SMILES CNc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N4OS/c1-14-12-16-17-7-9(15-13(17)19-12)11-6-8-4-2-3-5-10(8)18-11/h2-7H,1H3,(H,14,16)
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 mins fol...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 5 mins followed...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364570
PNG
(6-(6,7-Dimethoxybenzofuran-2-yl)-2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)c(OC)c2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-10-5-4-8-6-11(22-12(8)13(10)20-2)9-7-18-14(16-9)23-15(17-18)21-3/h4-7H,1-3H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50528286
PNG
(CHEMBL4471641)
Show SMILES CS(=O)(=O)c1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3O3S2/c1-21(17,18)13-15-16-7-9(14-12(16)20-13)11-6-8-4-2-3-5-10(8)19-11/h2-7H,1H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364634
PNG
(US9862730, Example 93)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC)ccc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-9-3-4-11-8(5-9)6-12(20-11)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364634
PNG
(US9862730, Example 93)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC)ccc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-9-3-4-11-8(5-9)6-12(20-11)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3
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Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Cytochrome P450 4B1


(Homo sapiens)		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CYP450 in human liver microsomes

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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n/an/an/an/a>5.00E+4n/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Activation of human PXR

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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n/an/an/a 1.40n/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Displacement of [3H]BMS-986120 from His-tagged human PAR4 expressed in HEK293 cell membranes measured after 2 hrs

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
UniProtKB/SwissProt

antibodypedia
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MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 3n/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Displacement of [3H]BMS-986120 from His-tagged human PAR4 expressed in HEK293 cell membranes

J Med Chem 62: 7400-7416 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00186
BindingDB Entry DOI: 10.7270/Q2QC06ZZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%