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TargetProteinase-activated receptor 4
LigandBDBM364569
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1904768 (CHEMBL4407126)
IC50 240±n/a nM
Citation Miller, MM; Banville, J; Friends, TJ; Gagnon, M; Hangeland, JJ; Lavallée, JF; Martel, A; O'Grady, H; Rémillard, R; Ruediger, E; Tremblay, F; Posy, SL; Allegretto, NJ; Guarino, VR; Harden, DG; Harper, TW; Hartl, K; Josephs, J; Malmstrom, S; Watson, C; Yang, Y; Zhang, G; Wong, P; Yang, J; Bouvier, M; Seiffert, DA; Wexler, RR; Lawrence, RM; Priestley, ES; Marinier, A Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy. J Med Chem62:7400-7416 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proteinase-activated receptor 4
Name:Proteinase-activated receptor 4
Synonyms:Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:Protein
Mol. Mass.:41145.16
Organism:Homo sapiens (Human)
Description:Q96RI0
Residue:385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM364569
n/a
NameBDBM364569
Synonyms:2-Methoxy-6-(7-methoxybenzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole | US9862730, Example 35 | US9862730, Example 9
TypeSmall organic molecule
Emp. Form.C14H11N3O3S
Mol. Mass.301.32
SMILESCOc1nn2cc(nc2s1)-c1cc2cccc(OC)c2o1
Structure
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